Corey–Seebach reaction

Corey–Seebach reaction
Named after Elias James Corey
Dieter Seebach
Reaction type Coupling reaction
Identifiers
Organic Chemistry Portal corey-seebach-reaction

The Corey–Seebach reaction, or Seebach Umpolung is a name reaction of organic chemistry that allows for acylation by converting aldehydes into lithiated 1,3-dithianes. The lithiated 1,3-dithianes serves as an acyl anion equivalent, undergoing alkylation with electrophiles.[1] The reaction is named in honor of its discoverers, Elias J. Corey and Dieter Seebach.

  1. ^ Smith, Amos B.; Adams, Christopher M. (6 May 2004). "Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products". Accounts of Chemical Research. 37 (6): 365–377. doi:10.1021/ar030245r. PMID 15196046.
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