Crabbé reaction

The Crabbé reaction (or Crabbé allene synthesis, Crabbé–Ma allene synthesis) is an organic reaction that converts a terminal alkyne and aldehyde (or, sometimes, a ketone) into an allene in the presence of a soft Lewis acid catalyst (or stoichiometric promoter) and secondary amine.[1][2] Given continued developments in scope and generality, it is a convenient and increasingly important method for the preparation of allenes, a class of compounds often viewed as exotic and synthetically challenging to access.

  1. ^ Brummond, Kay M.; DeForrest, Jolie E. (March 2007). "Synthesizing Allenes Today (1982-2006)". Synthesis. 2007 (6): 795–818. doi:10.1055/s-2007-965963. ISSN 0039-7881.
  2. ^ Huang, Xin; Ma, Shengming (2019-04-15). "Allenation of Terminal Alkynes with Aldehydes and Ketones". Accounts of Chemical Research. 52 (5): 1301–1312. doi:10.1021/acs.accounts.9b00023. ISSN 0001-4842. PMID 30985104.
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