Schotten–Baumann reaction

Schotten-Baumann reaction
Named after Carl Schotten
Eugen Baumann
Reaction type Condensation reaction
Identifiers
Organic Chemistry Portal schotten-baumann-reaction
RSC ontology ID RXNO:0000165

The Schotten–Baumann reaction is a method to synthesize amides from amines and acid chlorides:

Schotten–Baumann reaction conditions can also refer to the formation of esters by reaction of an acyl chloride with a primary or secondary alcohol. The reaction was first described in 1883 by German chemists Carl Schotten and Eugen Baumann.[1][2]

The name "Schotten–Baumann reaction conditions" often indicate the use of a two-phase solvent system, consisting of water and an organic solvent. The base in the water phase neutralizes the acid generated by the reaction while the starting materials and product remain in the organic phase, often dichloromethane or diethyl ether.

  1. ^ W Pötsch. Lexikon bedeutender Chemiker (VEB Bibliographisches Institut Leipzig, 1989) (ISBN 3-323-00185-0)
  2. ^ M B Smith, J March. March's Advanced Organic Chemistry (Wiley, 2001) (ISBN 0-471-58589-0)
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.