α-Pyrrolidinohexiophenone

α-Pyrrolidinohexiophenone
Clinical data
Routes of; administration	Oral, intranasal, vaporization, intravenous, rectal, sublingual, subcutaneous
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; UN: Psychotropic Schedule II; Illegal in China, Sweden and Italy;
Identifiers
	IUPAC name (RS)-1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one;
CAS Number	13415-86-6 ; HCl: 13415-59-3 ;
PubChem CID	102107923;
ChemSpider	52084419;
UNII	297J9K8A4G; HCl: Z5DJ7QN981 ;
KEGG	C22753;
CompTox Dashboard (EPA)	DTXSID301016924 ;
Chemical and physical data
Formula	C16H23NO
Molar mass	245.366 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1(=CC=CC=C1)C(C(CCCC)N2CCCC2)=O;
	InChI InChI=1S/C16H23NO/c1-2-3-11-15(17-12-7-8-13-17)16(18)14-9-5-4-6-10-14/h4-6,9-10,15H,2-3,7-8,11-13H2,1H3; Key:KYIJLDDXQWBNGX-UHFFFAOYSA-N;

α-Pyrrolidinohexiophenone (α-PHP, A-PHP, Aphp, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s^[2] which has been reported as a novel designer drug.^[3]^[4]^[5]^[6]^[7]

^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
^ US patent 3314970, Ernst Seeger, "α-Pyrrolidino ketones", published 1967-04-18, issued 1967-04-18, assigned to Boehringer Lagelheim G.m.b.H.
^ Uchiyama N, Shimokawa Y, Kawamura M, Kikura-Hanajiri R, Hakamatsuka T (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products". Forensic Toxicology. 32 (2): 266–281. doi:10.1007/s11419-014-0238-5. S2CID 11873421.
^ Majchrzak M, Rojkiewicz M, Celiński R, Kuś P, Sajewicz M (October 2015). "Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials". Forensic Toxicology. 34: 115–124. doi:10.1007/s11419-015-0295-4. PMC 4705138. PMID 26793278.
^ Paul M, Bleicher S, Guber S, Ippisch J, Polettini A, Schultis W (November 2015). "Identification of phase I and II metabolites of the new designer drug α-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)". Journal of Mass Spectrometry. 50 (11): 1305–1317. Bibcode:2015JMSp...50.1305P. doi:10.1002/jms.3642. PMID 26505776.
^ Klavž J, Gorenjak M, Marinšek M (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018. PMID 26890319.
^ Grapp M, Kaufmann C, Schwelm HM, Neukamm MA (March 2023). "Toxicological Investigation of a Case Series Involving the Synthetic Cathinone α-Pyrrolidinohexiophenone (α-PHP) and Identification of Phase I and II Metabolites in Human Urine". Journal of Analytical Toxicology. 47 (2): 162–174. doi:10.1093/jat/bkac057. PMID 35921233.

[1] Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.

[2] US patent 3314970, Ernst Seeger, "α-Pyrrolidino ketones", published 1967-04-18, issued 1967-04-18, assigned to Boehringer Lagelheim G.m.b.H.

[3] Uchiyama N, Shimokawa Y, Kawamura M, Kikura-Hanajiri R, Hakamatsuka T (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products". Forensic Toxicology. 32 (2): 266–281. doi:10.1007/s11419-014-0238-5. S2CID 11873421.

[4] Majchrzak M, Rojkiewicz M, Celiński R, Kuś P, Sajewicz M (October 2015). "Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials". Forensic Toxicology. 34: 115–124. doi:10.1007/s11419-015-0295-4. PMC 4705138. PMID 26793278.

[5] Paul M, Bleicher S, Guber S, Ippisch J, Polettini A, Schultis W (November 2015). "Identification of phase I and II metabolites of the new designer drug α-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)". Journal of Mass Spectrometry. 50 (11): 1305–1317. Bibcode:2015JMSp...50.1305P. doi:10.1002/jms.3642. PMID 26505776.

[6] Klavž J, Gorenjak M, Marinšek M (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018. PMID 26890319.

[7] Grapp M, Kaufmann C, Schwelm HM, Neukamm MA (March 2023). "Toxicological Investigation of a Case Series Involving the Synthetic Cathinone α-Pyrrolidinohexiophenone (α-PHP) and Identification of Phase I and II Metabolites in Human Urine". Journal of Analytical Toxicology. 47 (2): 162–174. doi:10.1093/jat/bkac057. PMID 35921233.

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