1-Methylnicotinamide

1-Methylnicotinamide
Names
	Preferred IUPAC name 3-Carbamoyl-1-methylpyridin-1-ium
	Other names Trigonellamide; N1-Methylnicotinamide; NMN
Identifiers
CAS Number	3106-60-3; 1005-24-9(chloride);
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16797;
ChEMBL	ChEMBL71733;
ChemSpider	444;
PubChem CID	457;
UNII	UM47085BXC;
CompTox Dashboard (EPA)	DTXSID10185019 ;
	SMILES C[N+]1=CC=CC(=C1)C(=O)N;
Properties
Chemical formula	C7H9N2O+
Molar mass	137.161 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

1-Methylnicotinamide (1-MNA, trigonellamide) is a prototypic organic cation.^[1] 1-Methylnicotinamide is the methylated amide of nicotinamide (niacinamide, vitamin B₃).

1-Methylnicotinamide is an endogenic substance that is produced in the liver when nicotinamide is metabolized. It is a typical substance secreted in the kidney. It participates in the nicotinamide salvage pathway within the NAD⁺ (nicotinamide adenine dinucleotide) metabolic pathway, thereby contributing to optimizing NAD⁺ levels.^[2]

^ Sokol, P. P.; Holohan, P. D.; Ross, C. R. (1986). "Essential disulfide and sulfhydryl groups for organic cation transport in renal brush-border membranes". Journal of Biological Chemistry. 261 (7): 3282–3287. doi:10.1016/S0021-9258(17)35779-4. PMID 2936734. Retrieved 5 March 2021.
^ Li, Jing-Jing; Sun, Wei-Dong; Zhu, Xiao-Juan; Mei, Ya-Zhong; Li, Wen-Song; Li, Jiang-Hua (2024-06-19). "Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions". Metabolites. 14 (6): 343. doi:10.3390/metabo14060343. ISSN 2218-1989. PMC 11205546. PMID 38921477.

[1] Sokol, P. P.; Holohan, P. D.; Ross, C. R. (1986). "Essential disulfide and sulfhydryl groups for organic cation transport in renal brush-border membranes". Journal of Biological Chemistry. 261 (7): 3282–3287. doi:10.1016/S0021-9258(17)35779-4. PMID 2936734. Retrieved 5 March 2021.

[:0-2] Li, Jing-Jing; Sun, Wei-Dong; Zhu, Xiao-Juan; Mei, Ya-Zhong; Li, Wen-Song; Li, Jiang-Hua (2024-06-19). "Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions". Metabolites. 14 (6): 343. doi:10.3390/metabo14060343. ISSN 2218-1989. PMC 11205546. PMID 38921477.

[1]

[2]