6-APBT
| Clinical data | |
|---|---|
| Other names | 6-(2-Aminopropyl)-1-benzothiophene; 6-APBT; 6-APBTP |
| Drug class | Serotonin–norepinephrine–dopamine releasing agent; Serotonin 5-HT2 receptor agonist; Entactogen; Serotonergic psychedelic |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C11H13NS |
| Molar mass | 191.29 g·mol−1 |
| 3D model (JSmol) | |
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6-(2-Aminopropyl)-1-benzothiophene (6-APBT) is a monoamine releasing agent and serotonin receptor agonist of the amphetamine and benzothiophene families.[1][2] It is related to MDA and other MDA bioisosteres like the benzofurans.[1][2]
The drug acts as a potent and well-balanced serotonin–norepinephrine–dopamine releasing agent (SNDRA) and full agonist of the serotonin 5-HT2 receptors.[2] 6-APBT does not increase locomotor activity in rodents and hence does not appear to have stimulant-like effects.[2] However, it does produce the head-twitch response, a behavioral proxy of psychedelic effects, and hence may have hallucinogenic effects.[2]
6-APBT was first described in the scientific literature by 2020.[1][2]
- ^ a b c Brandt SD, Carlino L, Kavanagh PV, Westphal F, Dreiseitel W, Dowling G, et al. (August 2020). "Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants". Drug Testing and Analysis. 12 (8): 1109–1125. doi:10.1002/dta.2813. PMC 8281332. PMID 32372465.
- ^ a b c d e f Rudin D, McCorvy JD, Glatfelter GC, Luethi D, Szöllősi D, Ljubišić T, et al. (March 2022). "(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice". Neuropsychopharmacology. 47 (4): 914–923. doi:10.1038/s41386-021-01221-0. PMC 8882185. PMID 34750565.