HU-243

HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a methylene homologue of canbisol. It is a potent agonist at both the CB₁ and CB₂ receptors, with a binding affinity of 0.041 nM at the CB₁ receptor, making it marginally more potent than HU-210, which had an affinity of 0.061 nM in the same assay.^[1]

With an affinityvalue of 0.043nM, this cannabinoide is ranged in the most potent (synthetic) cannabinoids. But there are more potent cannabinoids with the chemical structure of the JWH-cannabinoids (JWh-250, and JWH-210) which are demonstrating affinityvalues up to 0.000952- and 0.00654nM in respective. JWH-015 ranges in the nanomolar ability of HU-210- and 250 with 0.068nM slightly above HU-210 its potency (0.061nM).^[2] so the signatory countries to these international drug control treaties are not required by said treaties to control HU-243.