Acedapsone

Acedapsone
Clinical data
Trade names	Rodilone; Hansolar
ATC code	none;
Identifiers
	IUPAC name N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide;
CAS Number	77-46-3 ;
PubChem CID	6477;
ChemSpider	6232 ;
UNII	0GZ72U84TN;
KEGG	D02751 ;
ChEMBL	ChEMBL154166 ;
CompTox Dashboard (EPA)	DTXSID1021295 ;
ECHA InfoCard	100.000.936
Chemical and physical data
Formula	C16H16N2O4S
Molar mass	332.37 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	290 °C (554 °F)
	SMILES CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C;
	InChI InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20) ; Key:AMTPYFGPPVFBBI-UHFFFAOYSA-N ;
	(what is this?) (verify)

Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity.

Acedapsone is the INN for diacetyldapsone. It was synthesized and developed in 1937 by Ernest Fourneau and his team in the pharmaceutical chemistry laboratory of Pasteur Institute,^[1] and it was marketed as Rodilone by the Rhône-Poulenc company.^[2]

It is a long-acting prodrug of dapsone. It is used for treating leprosy.^[3]

It crystallises as pale yellow needles from diethyl ether, and as leaflets from dilute ethanol. It is slightly soluble in water.

^ Fourneau E, Tréfouël J, Nitti F, Bovet D (July 1937). "Chimiothérapie de l'infection pneumococcique par la di-(p-acétylaminophényl)-sulfone (1399 F)". Compt. Rend. Acad. Sci. (in French). 205: 299.
^ Fourneau JP (1987). "Ernest Fourneau, fondateur de la chimie thérapeutique française: feuillets d'album". Revue d'Histoire de la Pharmacie (in French). 75 (275): 335–55. doi:10.3406/pharm.1987.2904.
^ Shaw IN, Christian M, Jesudasan K, Kurian N, Rao GS (June 2003). "Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity". Leprosy Review. 74 (2): 141–7. doi:10.47276/lr.74.2.141. PMID 12862255.

[1] Fourneau E, Tréfouël J, Nitti F, Bovet D (July 1937). "Chimiothérapie de l'infection pneumococcique par la di-(p-acétylaminophényl)-sulfone (1399 F)". Compt. Rend. Acad. Sci. (in French). 205: 299.

[2] Fourneau JP (1987). "Ernest Fourneau, fondateur de la chimie thérapeutique française: feuillets d'album". Revue d'Histoire de la Pharmacie (in French). 75 (275): 335–55. doi:10.3406/pharm.1987.2904.

[pmid12862255-3] Shaw IN, Christian M, Jesudasan K, Kurian N, Rao GS (June 2003). "Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity". Leprosy Review. 74 (2): 141–7. doi:10.47276/lr.74.2.141. PMID 12862255.

[1]

[2]

[3]