Alemtuzumab

Alemtuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from rat)
TargetCD52
Clinical data
Trade namesCampath, Mabcampath, Lemtrada, others
AHFS/Drugs.comMonograph
MedlinePlusa608053
License data
Pregnancy
category
Routes of
administration		Intravenous infusion
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life~288 hrs
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC6468H10066N1732O2005S40
Molar mass145454.20 g·mol−1
 NY (what is this?)  (verify)

Alemtuzumab, sold under the brand names Campath and Lemtrada among others, is a medication used to treat chronic lymphocytic leukemia and multiple sclerosis.[7] In chronic lymphocytic leukemia, it has been used as both a first line and second line treatment.[7] It is given by injection into a vein.[7]

It is a monoclonal antibody that binds to CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes are derived. After treatment with alemtuzumab, these CD52-bearing lymphocytes are targeted for destruction.

Alemtuzumab was approved for medical use in the United States in 2001.[7] (Mab)Campath was withdrawn from the markets in the US and the EU in 2012, to prepare for a higher-priced relaunch of Lemtrada aimed at multiple sclerosis.[8]

  1. ^ "Alemtuzumab Use During Pregnancy". Drugs.com. 22 August 2022. Retrieved 6 January 2024.
  2. ^ "TGA eBS - Product and Consumer Medicine Information Licence".
  3. ^ "TGA eBS - Product and Consumer Medicine Information Licence".
  4. ^ "Campath- alemtuzumab injection". DailyMed. 3 May 2023. Retrieved 6 January 2024.
  5. ^ "Lemtrada- alemtuzumab injection, solution, concentrate". DailyMed. 23 May 2023. Retrieved 6 January 2024.
  6. ^ "Lemtrada EPAR". European Medicines Agency. 12 September 2013. Retrieved 6 January 2024.
  7. ^ a b c d "Alemtuzumab Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 15 July 2019.
  8. ^ Cite error: The named reference pt was invoked but never defined (see the help page).
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