Orosomucoid

Orosomucoid (ORM) or alpha-1-acid glycoprotein (α1AGp,[1] AGP or AAG) is an acute phase protein found in plasma. Orosomucoid was discovered over 70 years ago and belongs to the lipocalin protein family.[2] There are two isoforms of AGP, referred to as AGP1 and AGP2.[2] It is an alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6–1.2 mg/mL (1–3% plasma protein).[3] Recent research has shown that under certain physiological conditions, brain and adipose tissue can also synthesize this protein.[2] Plasma levels of AGP are affected by pregnancy, burns, certain drugs, and certain diseases, particularly HIV.[3] APG also plays an important role in inflammation and pharmacokinetics, acting as a major transport protein in the blood stream.[4][5]

  1. ^ Cite error: The named reference loganabbrev was invoked but never defined (see the help page).
  2. ^ a b c Ruiz, Mario (2021-06-08). "Into the Labyrinth of the Lipocalin α1-Acid Glycoprotein". Frontiers in Physiology. 12 686251. doi:10.3389/fphys.2021.686251. ISSN 1664-042X. PMC 8217824. PMID 34168570.
  3. ^ a b Colombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL, Biollaz J, Eap CB (October 2006). "Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation". Clinical Pharmacology and Therapeutics. 80 (4): 307–18. doi:10.1016/j.clpt.2006.06.006. PMID 17015049. S2CID 684478.
  4. ^ Ceciliani, Fabrizio; Lecchi, Cristina (2019). "The Immune Functions of α1 Acid Glycoprotein". Current Protein & Peptide Science. 20 (6): 505–524. doi:10.2174/1389203720666190405101138. PMID 30950347.
  5. ^ "UniProt". UniProt. Retrieved 2025-05-09.
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