Ameloblastic fibro-odontoma
| Ameloblastic fibro-odontoma | |
|---|---|
| Specialty | Dentistry. |
| Symptoms | Tooth eruption failure.[1] |
| Complications | Sinus destruction, facial disfigurement, perforated cortical plates.[2] |
| Usual onset | First and second decade of life.[3] |
| Frequency | Rare. |
The ameloblastic fibro-odontoma (AFO) is essentially a benign tumor with the features characteristic of ameloblastic fibroma along with enamel and dentin (hard tissues).[4] Though it is generally regarded as benign, there have been cases of its malignant transformation into ameloblastic fibrosarcoma[5] and odontogenic sarcoma.[6] Cahn LR and Blum T, believed in "maturation theory", which suggested that AFO was an intermediate stage and eventually developed during the period of tooth formation to a complex odontoma thus, being a hamartoma.[7]
World Health Organization (WHO) defines AFO as a neoplasm consisting of odontogenic ectomesenchyme resembling the dental papilla, epithelial strands and nest resembling dental lamina and enamel organ conjunction with the presence of dentine and enamel. There is a consensus that AFO should be grouped under Odontomas. This is because once the hard tissues start forming it will eventually lead to formation of Odontomas.[8] The Recent WHO classification published in 2017
has grouped AFDs into odontomes.[9][10] According to Tekkesin S et al, combination of age and lesion size should be used to distinguish between lesions of a true neoplastic nature and hamartomatous formation.[11]
- ^ Cite error: The named reference
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Neville_2009was invoked but never defined (see the help page). - ^ Surej Kumar LK, Manuel S, Khalam SA, Venugopal K, Sivakumar TT, Issac J (2014). "Ameloblastic fibro-odontoma". International Journal of Surgery Case Reports. 5 (12): 1142–1144. doi:10.1016/j.ijscr.2014.11.025. PMC 4276268. PMID 25437658.
- ^ Howell RM, Burkes EJ (March 1977). "Malignant transformation of ameloblastic fibro-odontoma to ameloblastic fibrosarcoma". Oral Surgery, Oral Medicine, and Oral Pathology. 43 (3): 391–401. doi:10.1016/0030-4220(77)90326-7. PMID 265043.
- ^ Herzog U, Putzke HP, Bienengräber V, Radke C (March 1991). "[The ameloblastic fibro-odontoma--an odontogenic mixed tumor progressing into an odontogenic sarcoma]". Deutsche Zeitschrift für Mund-, Kiefer- und Gesichts-Chirurgie. 15 (2): 90–93. PMID 1816940.
- ^ Trachoo V, Vipismakul V (2019). "Ameloblastic Fibro-odontoma or Immature Odontoma: A Retrospective Analysis of 134 Cases". Journal of Clinical and Diagnostic Research. doi:10.7860/jcdr/2019/42144.13154. ISSN 2249-782X. S2CID 204060859.
- ^ Wright JM, Vered M (March 2017). "Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors". Head and Neck Pathology. 11 (1): 68–77. doi:10.1007/s12105-017-0794-1. PMC 5340735. PMID 28247226.
- ^ Speight PM, Takata T (March 2018). "New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours". Virchows Archiv. 472 (3): 331–339. doi:10.1007/s00428-017-2182-3. PMC 5886999. PMID 28674741.
- ^ Westra WH, Lewis JS (March 2017). "Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx". Head and Neck Pathology. 11 (1): 41–47. doi:10.1007/s12105-017-0793-2. PMC 5340734. PMID 28247229.
- ^ Soluk-Tekkesin M, Vered M (December 2021). "Ameloblastic Fibro-Odontoma: At the Crossroad Between "Developing Odontoma" and True Odontogenic Tumour". Head and Neck Pathology. 15 (4): 1202–1211. doi:10.1007/s12105-021-01332-6. PMC 8633217. PMID 33991318.