Amelogenesis

Amelogenesis is the process of forming tooth enamel, the hard, protective outer layer of teeth.[1] This process begins during tooth development after the initial formation of dentin (dentinogenesis), the layer beneath the enamel.[2] The inner enamel epithelium (IEE), a layer of cells within the developing tooth, plays a crucial role by signaling the differentiation of specialized cells called ameloblasts,[3] which then secrete the proteins and minerals that make up enamel.[4] The formation of dentin is essential for amelogenesis to occur, and a reciprocal signaling process between the developing dentin and the IEE-derived ameloblasts ensures the proper coordination of these two crucial stages of tooth development.

  1. ^ Lacruz RS, Habelitz S, Wright JT, Paine ML (July 2017). "Dental Enamel Formation and Implications for Oral Health and Disease". Physiological Reviews. 97 (3): 939–993. doi:10.1152/physrev.00030.2016. PMC 6151498. PMID 28468833.
  2. ^ Rathee M, Jain P (2025). "Embryology, Teeth". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 32809350. Retrieved 2025-01-29.
  3. ^ Yoshizaki K, Fukumoto S, Bikle DD, Oda Y (November 2020). "Transcriptional Regulation of Dental Epithelial Cell Fate". International Journal of Molecular Sciences. 21 (23): 8952. doi:10.3390/ijms21238952. PMC 7728066. PMID 33255698.
  4. ^ Bei M (July 2009). "Molecular genetics of ameloblast cell lineage". Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution. 312B (5): 437–444. Bibcode:2009JEZB..312..437B. doi:10.1002/jez.b.21261. PMC 2737325. PMID 19090561.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.