Diatrizoate

Diatrizoate
Clinical data
Trade names	Hypaque, Gastrografin, Iothalmate, others
Other names	amidotrizoic acid, diatrizoic acid, 3,5-diacetamido-2,4,6-triiodobenzoic acid
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	V08AA01 (WHO) ;
Identifiers
	IUPAC name 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid;
CAS Number	737-31-5;
PubChem CID	2140;
DrugBank	DB00271;
ChemSpider	2055;
UNII	5UVC90J1LK; V5403H8VG7;
KEGG	D02240;
ChEBI	CHEBI:53691;
ChEMBL	ChEMBL1201220;
CompTox Dashboard (EPA)	DTXSID0044521 ;
ECHA InfoCard	100.003.840
Chemical and physical data
Formula	C11H9I3N2O4
Molar mass	613.916 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)NC(=O)C)I;
	InChI InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20); Key:YVPYQUNUQOZFHG-UHFFFAOYSA-N;

Diatrizoate, also known as amidotrizoate, Gastrografin, is a contrast agent used during X-ray imaging.^[1] This includes visualizing veins, the urinary system, spleen, and joints, as well as computer tomography (CT scan).^[1] It is given by mouth, injection into a vein, injection into the bladder, through a nasogastric tube, or rectally.^[2]^[3]

Relatively common side effects include vomiting, diarrhea, and skin redness.^[4] Other side effects include itchiness, kidney problems, low blood pressure, and allergic reactions.^[1] It is not recommended in people who have an iodine allergy.^[1] Diatrizoate is an iodinated ionic radiocontrast agent with high osmolality.^[2]

Diatrizoate was approved for medical use in the United States in 1954.^[4] It is on the World Health Organization's List of Essential Medicines.^[5]

^ ^a ^b ^c ^d World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 316. hdl:10665/44053. ISBN 9789241547659.
^ ^a ^b Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 171. ISBN 9781284057560.
^ Pollack HM (2012). "History of Iodinated Contrast Media". In Thomsen H, Muller RN, Mattrey RF (eds.). Trends in Contrast Media. Springer Science & Business Media. p. 13. ISBN 9783642598142. Archived from the original on 1 January 2017.
^ ^a ^b "Diatrizoate Side Effects in Detail". Drugs.com. Archived from the original on 1 January 2017. Retrieved 31 December 2016.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.