Anti–Saccharomyces cerevisiae antibody
| Antigen isoform | Mannans |
|---|---|
| Antigen source | Saccharomyces cerevisiae |
| Antigen gene | pro |
| Affected organ(s) | Large Intestine |
| Affected tissue(s) | Epithelium |
| Associated disease(s) | Colitis |
Anti-Saccharomyces cerevisiae antibodies (ASCAs) are antibodies against antigens presented by the cell wall of the yeast Saccharomyces cerevisiae. These antibodies are directed against oligomannose sequences α-1,3 Man (α-1,2 Man α-1,2 Man)n (n = 1 or 2).[1] ASCAs and perinuclear antineutrophil cytoplasmic antibodies (pANCAs) are the two most useful and often discriminating biomarkers for colitis.[2] ASCA tends to recognize Crohn's disease more frequently, whereas pANCA tend to recognize ulcerative colitis.[3]
ASCA antibodies react to a yeast protein with mannans,[4] a 200-kDa glycoprotein.[5]
- ^ Standaert-Vitse A, Jouault T, Vandewalle P, Mille C, Seddik M, Sendid B, Mallet JM, Colombel JF, Poulain D (2006). "Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease". Gastroenterology. 130 (6): 1764–75. doi:10.1053/j.gastro.2006.02.009. PMID 16697740.
- ^ Desplat-Jégo S, Johanet C, Escande A, et al. (2007). "Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicenter study". World J. Gastroenterol. 13 (16): 2312–8. doi:10.3748/wjg.v13.i16.2312. PMC 4147139. PMID 17511029.
- ^ Joossens S, Reinisch W, Vermeire S, et al. (2002). "The value of serologic markers in indeterminate colitis: a prospective follow-up study". Gastroenterology. 122 (5): 1242–1247. doi:10.1053/gast.2002.32980. PMID 11984510.
- ^ Lindberg E, Magnusson KE, Tysk C, Järnerot G (1992). "Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease". Gut. 33 (7): 909–913. doi:10.1136/gut.33.7.909. PMC 1379403. PMID 1644330.
- ^ Heelan BT, Allan S, Barnes RM (1991). "Identification of a 200-kDa glycoprotein antigen of Saccharomyces cerevisiae". Immunol. Lett. 28 (3): 181–185. doi:10.1016/0165-2478(91)90001-Q. PMID 1885214.