Antiganglioside antibodies
| Autoantibody | |
|---|---|
| Anti-ganglioside | |
| Common autoantibody characteristics | |
| Triggering agent(s) |
Campylobacter jejuni (Major)
Mycoplasma pneumoniae (Minor) Coeliac Disease(Rare) |
| Isoform specific | |
| autoantibody characteristics | |
| Autoantigen Isoform |
Ganglioside D3 (GD3) |
| Affected Organ(s) | Muscle |
| Affected Cells(s) | motor nerve terminal (nodes of Ranvier) |
| Associated Disease(s) |
Guillain–Barré syndrome |
| Autoantibody class | IgA |
| Autoantigen Isoform |
Ganglioside M1 (GM1) |
| Associated Disease(s) |
prodromal diarrhea |
| Autoantibody class | IgG |
| IgG Subclass | IgG1, IgG3, IgG4 |
| Autoantigen Isoform |
Ganglioside Q1b (GQ1b) |
| Affected Cells(s) | Schwann cells |
| Associated Disease(s) |
Miller-Fisher Syndrome |
Antiganglioside antibodies that react to self-gangliosides are found in autoimmune neuropathies. These antibodies were first found to react with cerebellar cells.[1] These antibodies show highest association with certain forms of Guillain–Barré syndrome.
- ^ Gregson NA, Pytharas M, Leibowitz S (1977). "The reactivity of anti-ganglioside antiserum with isolated cerebellar cells". Biochem. Soc. Trans. 5 (1): 174–5. doi:10.1042/bst0050174. PMID 70385.