Arterial input function

Arterial input function (AIF), also known as a plasma input function, refers to the concentration of tracer in blood-plasma in an artery measured over time. The oldest record on PubMed shows that AIF was used by Harvey et al.[1] in 1962 to measure the exchange of materials between red blood cells and blood plasma, and by other researchers in 1983 for positron emission tomography (PET) studies.[2][3] Nowadays, kinetic analysis is performed in various medical imaging techniques, which requires an AIF as one of the inputs to the mathematical model, for example, in dynamic PET imaging,[4] or perfusion CT,[5] or dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).[6][7]

  1. ^ HARVEY, RB (1962). "Renal extraction of para-aminohippurate and creatinine measured by continuous in vivo sampling of arterial and renal-vein blood". Ann N Y Acad Sci. 102 (1): 46–54. Bibcode:1962NYASA.102...46H. doi:10.1111/j.1749-6632.1962.tb13624.x. PMID 13960801. S2CID 32041591.
  2. ^ Herscovitch, P (1983). "Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis". J. Nucl. Med. 24 (9): 782–9. PMID 6604139.
  3. ^ Henze, E.; Huang, S. C.; Ratib, O.; Hoffman, E.; Phelps, M. E.; Schelbert, H. R. (1983). "Measurements of regional tissue and blood-pool radiotracer concentrations from serial tomographic images of the heart". J Nucl Med. 24 (11): 987–96. PMID 6605418.
  4. ^ Cite error: The named reference :02 was invoked but never defined (see the help page).
  5. ^ Lui, Y.W.; Tang, E.R.; Allmendinger, A.M.; Spektor, V. (2010). "Evaluation of CT Perfusion in the Setting of Cerebral Ischemia: Patterns and Pitfalls". American Journal of Neuroradiology. 31 (9): 1552–1563. doi:10.3174/ajnr.a2026. ISSN 0195-6108. PMC 7965002. PMID 20190208.
  6. ^ Schabel, Matthias C. (2012-01-31). "A unified impulse response model for DCE-MRI". Magnetic Resonance in Medicine. 68 (5): 1632–1646. doi:10.1002/mrm.24162. ISSN 0740-3194. PMID 22294448.
  7. ^ Tanuj Puri, Sarah Wiscombe, Sally Marshall, John Simpson, Josephine Naish, Pete Thelwall. Changes in pulmonary vascular properties in a human model of acute lung injury measured using DCE-MRI, In 20th Annual Scientific Meeting of the British Chapter of International Society for Magnetic Resonance in Medicine (ISMRM), Edinburgh, UK, September 2014
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