Atopy
| Atopy | |
|---|---|
| Other names | Atopic syndrome |
| Eczema—a typical atopic manifestation | |
| Pronunciation |
|
| Specialty | Dermatology, immunology |
Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the environment.[2] Allergic diseases are clinical manifestations of such inappropriate, atopic responses.[2]
Atopy may have a hereditary component, although contact with the allergen or irritant must occur before the hypersensitivity reaction can develop (characteristically after re-exposure).[3] Maternal psychological trauma during pregnancy may also be a strong indicator for development of atopy.[4]
The term atopy was coined by Arthur F. Coca and Robert Cooke in 1923[5][6] from the Greek ἀτοπία meaning "the state of being out of place", "absurdity".[7] Many physicians and scientists use the term atopy for any reaction mediated by IgE (even those that are appropriate and proportional to the antigen), but many pediatricians reserve it to refer only to a genetically mediated predisposition to an excessive IgE reaction.[8]
- ^ Merriam-Webster Dictionary: Atopy
- ^ a b Ralston, Stuart H., Herausgeber. Penman, Ian D., Herausgeber. Strachan, Mark W. J., Herausgeber. Hobson, Richard P., Herausgeber. Britton, Robert, Illustrator. Davidson, Leybourne S. 1894-1981 Begründer des Werks. (2018-04-23). Davidson's principles and practice of medicine. Elsevier. ISBN 978-0-7020-7028-0. OCLC 1040673074.
{{cite book}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link) - ^ "Mosby's Medical Dictionary:atopy". Archived from the original on 2011-07-10.
- ^ Wright, Rosalind J; Enlow, Michelle Bosquet (2008-09-01). "Maternal stress and perinatal programming in the expression of atopy". Expert Review of Clinical Immunology. 4 (5): 535–538. doi:10.1586/1744666X.4.5.535. ISSN 1744-666X. PMC 2762209. PMID 19838310.
- ^ Coca AF, Cooke RA. (1923) On the classification of the phenomenon of hypersensitiveness J Immunol
- ^ Johannes Ring; Bernhard Przybilla; Thomas Ruzicka (2006). Handbook of atopic eczema. Birkhäuser. pp. 3–. ISBN 978-3-540-23133-2. Retrieved 4 May 2010.
- ^ "atopy". Online Etymology Dictionary. Douglas Harper. 2019. Retrieved 26 Sep 2019.
- ^ Ruby Pawankar; Stephen T. Holgate; Lanny J. Rosenwasser (7 April 2009). Allergy Frontiers: Classification and Pathomechanisms. Springer. pp. 33–. ISBN 978-4-431-88314-2. Retrieved 4 May 2010.