Autoimmune hemolytic anemia

Autoimmune hemolytic anemia
Other namesAutoimmune haemolytic anaemia
SpecialtyHematology 

Autoimmune hemolytic anemia (AIHA) occurs when a person's immune system produces antibodies directed against their own red blood cells (RBCs). These antibodies attach to red cells, causing them to break down (lyse), and reducing the number of oxygen-carrying red blood cells in circulation (anemia).[1][2] The antibodies are usually directed against common red cell antigens, therefore they also bind to allogenic or transfused red cells and cause them to lyse. (ref).[3][4][5] Autoimmune haemolytic anaemia can be caused by different types of antibodies with reactivity at different temperatures. The one caused by IgG antibodies is called warm-immune haemolytic anaemia and has an incidence of 5-10 cases per million whereas ‘cold agglutinin disease’ is caused by IgM antibodies with an incidence of 1-1.8 cases per million.

The terminology used in this disease is somewhat ambiguous. Although MeSH uses the term "autoimmune hemolytic anemia",[6] some sources prefer the term "immunohemolytic anemia" so drug reactions can be included in this category.[7][8] The National Cancer Institute considers "immunohemolytic anemia", "autoimmune hemolytic anemia", and "immune complex hemolytic anemia" to all be synonyms.[9]

  1. ^ Shoenfield, Y; et al. (2008). Diagnostic Criteria in Autoimmune Disease. Humana Press.
  2. ^ Sawitsky A, Ozaeta PB (June 1970). "Disease-associated autoimmune hemolytic anemia". Bull N Y Acad Med. 46 (6): 411–26. PMC 1749710. PMID 5267234.
  3. ^ Gehrs BC, Friedberg RC (April 2002). "Autoimmune hemolytic anemia". Am. J. Hematol. 69 (4): 258–71. doi:10.1002/ajh.10062. PMID 11921020. S2CID 22547733.
  4. ^ Berentsen, Sigbjørn; Barcellini, Wilma (7 October 2021). "Autoimmune Hemolytic Anemias". New England Journal of Medicine. 385 (15): 1407–1419. doi:10.1056/NEJMra2033982. PMID 34614331. S2CID 238423559.
  5. ^ Kokori, SI; Ioannidis, JP; Voulgarelis, M; Tzioufas, AG; Moutsopoulos, HM (2000-02-15). "Autoimmune hemolytic anemia in patients with systemic lupus erythematosus". The American Journal of Medicine. 108 (3): 198–204. doi:10.1016/S0002-9343(99)00413-1. ISSN 0002-9343. PMID 10723973.
  6. ^ Autoimmune+hemolytic+anemia at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  7. ^ Wright MS (1999). "Drug-induced hemolytic anemias: increasing complications to therapeutic interventions". Clin Lab Sci. 12 (2): 115–8. PMID 10387489.
  8. ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 636. ISBN 978-0-7216-0187-8.
  9. ^ "Definition of immunohemolytic anemia". NCI Dictionary of Cancer Terms. Archived from the original on 15 January 2009. Retrieved 2009-02-07.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.