Avelumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | PD-L1 |
| Clinical data | |
| Trade names | Bavencio |
| Other names | MSB0010718C |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a617006 |
| License data | |
| Pregnancy category |
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| Routes of administration | Intravenous infusion |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Metabolism | Proteolysis |
| Elimination half-life | 6.1 days |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6374H9898N1694O2010S44 |
| Molar mass | 143831.79 g·mol−1 |
Avelumab, sold under the brand name Bavencio, is a fully human monoclonal antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma.[5]
Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema).[7]
Avelumab targets the protein programmed death-ligand 1 (PD-L1). It has received orphan drug designation by the European Medicines Agency (EMA) for the treatment of gastric cancer in January 2017.[8] The US Food and Drug Administration (FDA) approved it in March 2017, for the treatment of Merkel-cell carcinoma,[7] an aggressive type of skin cancer. The EMA approved it in September 2017, for the same indication.[9] This is the first FDA-approved treatment for metastatic Merkel-cell carcinoma, a rare, aggressive form of skin cancer.[7] Avelumab was developed by Merck KGaA and Pfizer.[10]
- ^ "Avelumab (Bavencio) Use During Pregnancy". Drugs.com. 29 May 2019. Retrieved 2 August 2020.
- ^ "Regulatory Decision Summary for Bavencio". 23 October 2014.
- ^ "Cancer therapies". Health Canada. 8 May 2018. Retrieved 13 April 2024.
- ^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
- ^ a b "Bavencio- avelumab injection, solution, concentrate". DailyMed. 2 July 2020. Retrieved 2 August 2020.
- ^ "Bavencio EPAR". European Medicines Agency (EMA). 18 September 2017. Retrieved 15 June 2024.
- ^ a b c Cite error: The named reference
FDA PR 20170323was invoked but never defined (see the help page). - ^ "Public summary of opinion on orphan designation: Avelumab for the treatment of gastric cancer" (PDF). European Medicines Agency. 9 January 2017. Archived from the original (PDF) on 5 August 2017. Retrieved 29 April 2017.
- ^ "Bavencio: EPAR - Product Information" (PDF). European Medicines Agency. 18 September 2017. Archived from the original (PDF) on 17 June 2018. Retrieved 23 February 2018.
- ^ Merck-Pfizer Alliance. "Merck-Pfizer Alliance Avelumab Fact Sheet" (PDF). Archived from the original (PDF) on 17 May 2017. Retrieved 2 December 2015.