Bacterial outer membrane
| Lipopolysaccharide-assembly, LptC-related | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LptC | ||||||||
| Pfam | PF06835 | ||||||||
| Pfam clan | CL0259 | ||||||||
| InterPro | IPR010664 | ||||||||
| |||||||||
| Lipopolysaccharide-assembly | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LptE | ||||||||
| Pfam | PF04390 | ||||||||
| InterPro | IPR007485 | ||||||||
| TCDB | 1.B.42 | ||||||||
| OPM superfamily | 412 | ||||||||
| OPM protein | 4q35 | ||||||||
| |||||||||
The bacterial outer membrane is found in gram-negative bacteria. Gram-negative bacteria form two lipid bilayers in their cell envelopes - an inner membrane (IM) that encapsulates the cytoplasm, and an outer membrane (OM) that encapsulates the periplasm.[1]
The composition of the outer membrane is distinct from that of the inner cytoplasmic cell membrane - among other things, the outer leaflet of the outer membrane of many gram-negative bacteria includes a complex lipopolysaccharide whose lipid portion acts as an endotoxin - and in some bacteria such as E. coli it is linked to the cell's peptidoglycan by Braun's lipoprotein.
Porins can be found in this layer.[2]
- ^ Yeow J, Luo M, Chng SS (December 2023). "Molecular mechanism of phospholipid transport at the bacterial outer membrane interface". Nat Commun. 14 (1): 8285. Bibcode:2023NatCo..14.8285Y. doi:10.1038/s41467-023-44144-8. PMC 10719372. PMID 38092770.
- ^ van der Ley P, Heckels JE, Virji M, Hoogerhout P, Poolman JT (September 1991). "Topology of outer membrane porins in pathogenic Neisseria spp". Infection and Immunity. 59 (9): 2963–71. doi:10.1128/IAI.59.9.2963-2971.1991. PMC 258120. PMID 1652557.