Basiliximab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Chimeric (mouse/human) |
| Target | CD25 |
| Clinical data | |
| Trade names | Simulect |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a612013 |
| License data |
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| Routes of administration | Intravenous |
| Drug class | Immunosuppressants |
| ATC code | |
| Legal status | |
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| Pharmacokinetic data | |
| Elimination half-life | 7.2 days |
| Identifiers | |
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| DrugBank | |
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| Chemical and physical data | |
| Formula | C6378H9844N1698O1997S48 |
| Molar mass | 143801.68 g·mol−1 |
| (what is this?) (verify) | |
Basiliximab, sold under the brand name Simulect, is a monoclonal antibody used to prevent rejection in kidney transplants.[1][2] It is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells.[1] It is used in combination with other medicines used to prevent organ rejection.[1][2]
The most common side effects (seen in more than 20% of patients) include constipation, urinary tract infections (infection of the structures that carry urine), pain, nausea (feeling sick), peripheral oedema (swelling), hypertension (high blood pressure), anemia (low red blood cell counts), headache, hyperkalaemia (high blood potassium levels), hypercholesterolaemia (high blood cholesterol levels), surgical wound complication, weight increase, increased serum creatinine (a marker of kidney problems), hypophosphataemia (low blood phosphate levels), diarrhea and upper respiratory tract infection (colds).[2]
Basiliximab was approved for medical use in the United States and in the European Union in 1998.[1][2][3]
- ^ a b c d e "Simulect- basiliximab injection, powder, for solution". DailyMed. 6 October 2022. Archived from the original on 6 October 2022. Retrieved 27 February 2023.
- ^ a b c d e "Simulect EPAR". European Medicines Agency. 31 October 2009. Archived from the original on 11 January 2022. Retrieved 27 February 2023. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Basiliximab Product Approval Information - Licensing Action". U.S. Food and Drug Administration (FDA). 20 February 2009. Archived from the original on 13 January 2017. Retrieved 27 February 2023.