Benazepril

Benazepril
Clinical data
Pronunciation	/bəˈnæzəprɪl/
Trade names	Lotensin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a692011
License data	US DailyMed: Benazepril;
Routes of; administration	By mouth
ATC code	C09AA07 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	96.7%
Metabolism	Liver glucuronidation
Elimination half-life	10-11 hours
Excretion	Kidney and bile duct
Identifiers
	IUPAC name 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid;
CAS Number	86541-75-5 ;
PubChem CID	5362124;
IUPHAR/BPS	6374;
DrugBank	DB00542 ;
ChemSpider	4514935 ;
UNII	UDM7Q7QWP8;
KEGG	D07499; D00620;
ChEBI	CHEBI:3011 ;
ChEMBL	ChEMBL838 ;
CompTox Dashboard (EPA)	DTXSID5022645 ;
Chemical and physical data
Formula	C24H28N2O5
Molar mass	424.497 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3;
	InChI InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 ; Key:XPCFTKFZXHTYIP-PMACEKPBSA-N ;
	(verify)

Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.^[2] It is a reasonable initial treatment for high blood pressure.^[2] It is taken by mouth.^[2] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.^[2]

Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.^[2] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.^[2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.^[3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.^[2]

Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication.^[2] In 2022, it was the 159th most commonly prescribed medication in the United States, with more than 3 million prescriptions.^[4]^[5]

^ "Lotensin- benazepril hydrochloride tablet". DailyMed. 21 January 2019. Retrieved 11 February 2024.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Benazepril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ "Benazepril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
^ "Benazepril Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

[Lotensin_FDA_label-1] "Lotensin- benazepril hydrochloride tablet". DailyMed. 21 January 2019. Retrieved 11 February 2024.

[AHFS2019-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Benazepril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-3] "Benazepril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[4] "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.

[5] "Benazepril Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

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