Benperidol

Benperidol
Clinical data
Trade names	Anquil, Frenactil
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	N05AD07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Elimination half-life	8 hours
Identifiers
	IUPAC name 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;
CAS Number	2062-84-2 ;
PubChem CID	16363;
DrugBank	DB12867 ;
ChemSpider	15521 ;
UNII	97O6X78C53;
KEGG	D02627;
ChEBI	CHEBI:93403;
ChEMBL	ChEMBL297302 ;
CompTox Dashboard (EPA)	DTXSID7045364 ;
ECHA InfoCard	100.016.521
Chemical and physical data
Formula	C22H24FN3O2
Molar mass	381.451 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(cc1)C(=O)CCCN4CCC(N3c2ccccc2NC3=O)CC4;
	InChI InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28) ; Key:FEBOTPHFXYHVPL-UHFFFAOYSA-N ;
	(what is this?) (verify)

Benperidol, sold under the trade name Anquil^[1] among others, is a typical antipsychotic primarily used to treat hypersexuality syndromes^[2] and can be used to treat schizophrenia.^[3] It is a highly potent butyrophenone derivative and is the most potent neuroleptic in the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% the potency per dose of haloperidol).^[4] It is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.^[5]

Benperidol was discovered by Janssen Pharmaceutica in 1961 and has been marketed since 1966. It is mainly used in Germany, but it is also available in Belgium, Greece, the Netherlands, and the United Kingdom.^[6]

^ Council A, Kuenssberg V (1974-02-01). "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. 12 (3). BMJ Publishing Group Ltd: 12. doi:10.1136/dtb.12.3.12. PMID 4457302. S2CID 44581451.
^ British National Formulary (49th), British Medical Association 2005 p 183
^ Bobon J, Collard J, Lecoq R (October 1963). "[Benperidol and promazine: a "double blind" comparative study in mental geriatrics]". Acta Neurologica et Psychiatrica Belgica (in French). 63: 839–843. PMID 14092279.
^ Möller HJ, Müller WE, Bandelow (2001). Neuroleptika: pharmakologische Grundlagen, klinisches Wissen und therapeutisches Vorgehen; mit 136 Tabellen (in German). Wiss. Verlag-Ges. ISBN 978-3-8047-1773-2.
^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ (November 1975). "Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers". The Journal of Endocrinology. 67 (2): 179–188. doi:10.1677/joe.0.0670179. PMID 1107462.
^ "NCATS Inxight Drugs — BENPERIDOL". Retrieved 13 March 2022.

[1] Council A, Kuenssberg V (1974-02-01). "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. 12 (3). BMJ Publishing Group Ltd: 12. doi:10.1136/dtb.12.3.12. PMID 4457302. S2CID 44581451.

[2] British National Formulary (49th), British Medical Association 2005 p 183

[Bobon_1963-3] Bobon J, Collard J, Lecoq R (October 1963). "[Benperidol and promazine: a "double blind" comparative study in mental geriatrics]". Acta Neurologica et Psychiatrica Belgica (in French). 63: 839–843. PMID 14092279.

[4] Möller HJ, Müller WE, Bandelow (2001). Neuroleptika: pharmakologische Grundlagen, klinisches Wissen und therapeutisches Vorgehen; mit 136 Tabellen (in German). Wiss. Verlag-Ges. ISBN 978-3-8047-1773-2.

[Murray_1975-5] Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ (November 1975). "Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers". The Journal of Endocrinology. 67 (2): 179–188. doi:10.1677/joe.0.0670179. PMID 1107462.

[6] "NCATS Inxight Drugs — BENPERIDOL". Retrieved 13 March 2022.

[1]

[2]

[3]

[4]

[5]

[6]