Betaxolol

Betaxolol
Clinical data
Trade names	Kerlone
AHFS/Drugs.com	Monograph
MedlinePlus	a609023
Pregnancy; category	AU: C;
Routes of; administration	By mouth, ocular
Drug class	Beta blocker; β-Adrenergic receptor antagonist; Selective β1-adrenergic receptor antagonist
ATC code	C07AB05 (WHO) S01ED02 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	89%
Metabolism	Liver
Elimination half-life	14–22 hours
Excretion	Kidney (20%)
Identifiers
	IUPAC name (RS)-1-{4-[2-(cyclopropylmethoxy)ethyl]-; phenoxy}-3-(isopropylamino)propan-2-ol;
CAS Number	63659-18-7 ;
PubChem CID	2369;
IUPHAR/BPS	549;
DrugBank	DB00195 ;
ChemSpider	2279 ;
UNII	O0ZR1R6RZ2;
KEGG	D07526 ;
ChEBI	CHEBI:3082 ;
ChEMBL	ChEMBL423 ;
CompTox Dashboard (EPA)	DTXSID2022674 ;
ECHA InfoCard	100.113.058
Chemical and physical data
Formula	C18H29NO3
Molar mass	307.434 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O(CCc1ccc(OCC(O)CNC(C)C)cc1)CC2CC2;
	InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3 ; Key:NWIUTZDMDHAVTP-UHFFFAOYSA-N ;
	(verify)

Betaxolol is a beta blocker used in the treatment of hypertension and angina.^[1]

It acts as a selective β₁-adrenergic receptor antagonist.

The drug was patented in 1975 and approved for medical use in 1983.^[2]

^ Buckley MM, Goa KL, Clissold SP (July 1990). "Ocular betaxolol. A review of its pharmacological properties, and therapeutic efficacy in glaucoma and ocular hypertension". Drugs. 40 (1): 75–90. doi:10.2165/00003495-199040010-00005. PMID 2202584. S2CID 46962082.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495.