Birbeck granules

Birbeck granules, also known as Birbeck bodies, are rod shaped or "tennis-racket" cytoplasmic organelles found only in Langerhans cells.[1] Their appearance on electron microscopy is with a central linear density and a striated appearance. Although part of normal Langerhans cell histology, they also provide a mechanism to differentiate Langerhans cell histiocytoses (which are a group of rare conditions collectively known as histiocytoses) from proliferative disorders caused by other cell lines. Synthesis of Birbeck granules is mediated by langerin.[2]

  1. ^ Mc Dermott R, Ziylan U, Spehner D, et al. (January 2002). "Birbeck granules are subdomains of the endosomal recycling compartment in human epidermal Langerhans cells, which form where langerin accumulates". Mol. Biol. Cell. 13 (1): 317–35. doi:10.1091/mbc.01-06-0300. PMC 65091. PMID 11809842.
  2. ^ Kissenpfennig A, Aït-Yahia S, Clair-Moninot V, et al. (January 2005). "Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function". Mol. Cell. Biol. 25 (1): 88–99. doi:10.1128/MCB.25.1.88-99.2005. PMC 538791. PMID 15601833.
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