Brinzolamide

Brinzolamide
Clinical data
Pronunciation	brin ZOH la mide
Trade names	Azopt
Other names	(5R)-5-ethylamino-3-(3-methoxypropyl)-; 2,2-dioxo-2λ6,9-dithia-; 3-azabicyclo[4.3.0]nona-7,10-diene-; 8-sulfonamide
AHFS/Drugs.com	Monograph
MedlinePlus	a601233
License data	US DailyMed: Brinzolamide;
Pregnancy; category	AU: B3;
Routes of; administration	Ophthalmic
ATC code	S01EC04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	Absorbed systemically, but below detectable levels (less than 10 ng/mL)
Protein binding	~60%
Elimination half-life	111 days
Excretion	Kidney (60%)
Identifiers
	IUPAC name (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide;
CAS Number	138890-62-7 ;
PubChem CID	68844;
IUPHAR/BPS	6797;
DrugBank	DB01194 ;
ChemSpider	62077 ;
UNII	9451Z89515;
KEGG	D00652 ;
ChEBI	CHEBI:3176 ;
ChEMBL	ChEMBL220491 ;
CompTox Dashboard (EPA)	DTXSID6045531 ;
ECHA InfoCard	100.149.376
Chemical and physical data
Formula	C12H21N3O5S3
Molar mass	383.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1sc2c(c1)[C@@H](NCC)CN(CCCOC)S2(=O)=O)N;
	InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 ; Key:HCRKCZRJWPKOAR-JTQLQIEISA-N ;
	(verify)

Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Brinzolamide was approved as a generic medication in the United States in November 2020.^[2]

^ "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Retrieved 17 August 2020.
^ "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 12 June 2019. Retrieved 13 February 2021.

[Drugs.com_pregnancy-1] "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Retrieved 17 August 2020.

[2] "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 12 June 2019. Retrieved 13 February 2021.

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