Brodifacoum

Brodifacoum^[1]
Names
	IUPAC name 3-[3-[4-(4-Bromophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-2-hydroxychromen-4-one
	Other names Bromfenacoum
Identifiers
CAS Number	56073-10-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL233451 ;
ChemSpider	10444663 ;
ECHA InfoCard	100.054.509
PubChem CID	41736;
RTECS number	GN4934750;
UNII	A25P3CP5S7 ;
CompTox Dashboard (EPA)	DTXSID5032529 ;
	InChI InChI=1S/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2 Key: VEUZZDOCACZPRY-UHFFFAOYSA-N ; InChI=1/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2 Key: VEUZZDOCACZPRY-UHFFFAOYAI;
	SMILES Brc1ccc(cc1)c2ccc(cc2)C4Cc3ccccc3C(C4)C\5=C(/O)c6ccccc6OC/5=O;
Properties
Chemical formula	C31H23BrO3
Molar mass	523.426 g·mol−1
Melting point	228 to 230 °C (442 to 446 °F; 501 to 503 K)
Solubility in water	Insoluble
Pharmacology
Routes of; administration	Oral; dermal; inhalation (dusts) (for poisoning)
	Pharmacokinetics:
Bioavailability	100%
Metabolism	slow, incomplete, hepatic
Biological half-life	Slow; 20—130 days
Excretion	faeces; very slow
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	270 μg/kg (rat, oral)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Brodifacoum is a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison. In recent years, it has become one of the world's most widely used pesticides. It is typically used as a rodenticide, but is also used to control larger pests such as possums.^[2]

Brodifacoum has an especially long half-life in the body, which ranges up to nine months, requiring prolonged treatment with antidotal vitamin K for both human and pet poisonings. It has one of the highest risks of secondary poisoning to both mammals and birds.^[3] Significant experience in brodifacoum poisonings has been gained in many human cases where it has been used in attempted suicides, necessitating long periods of vitamin K treatment. In March 2018, cases of severe coagulopathy and bleeding associated with synthetic cannabinoid use contaminated with brodifacoum were reported in five states of the US.

^ Merck Index, 11th Edition, 1368
^ Eason, C.T. and Wickstrom, M. Vertebrate pesticide toxicology manual, New Zealand Department of Conservation
^ Rodenticides: Topic Fact Sheet, National Pesticide Information Center

[1] Merck Index, 11th Edition, 1368

[DoCManual-2] Eason, C.T. and Wickstrom, M. Vertebrate pesticide toxicology manual, New Zealand Department of Conservation

[NPICRodenticides-3] Rodenticides: Topic Fact Sheet, National Pesticide Information Center

[1]

[2]

[3]