Cancer exodus hypothesis

The cancer exodus hypothesis establishes that circulating tumor cell clusters (CTC clusters) maintain their multicellular structure throughout the metastatic process. It was previously thought that these clusters must dissociate into single cells during metastasis.[1] According to the hypothesis, CTC clusters intravasate (enter the bloodstream), travel through circulation as a cohesive unit, and extravasate (exit the bloodstream) at distant sites without disaggregating, significantly enhancing their metastatic potential. This concept is considered a key advancement in understanding of cancer biology and CTCs role in cancer metastasis.[2][3]

  1. ^ Ring A, Nguyen-Sträuli BD, Wicki A, Aceto N (February 2023). "Biology, vulnerabilities and clinical applications of circulating tumour cells". Nature Reviews. Cancer. 23 (2): 95–111. doi:10.1038/s41568-022-00536-4. PMC 9734934. PMID 36494603.
  2. ^ Cite error: The named reference Allen-2019 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Aceto-2014 was invoked but never defined (see the help page).
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