Starling equation

Not to be confused with the Frank–Starling law that describes the relationship between stroke volume and end diastolic volume.

The Starling principle holds that fluid movement across a semi-permeable blood vessel such as a capillary or small venule is determined by the hydrostatic pressures and colloid osmotic pressures (oncotic pressure) on either side of a semipermeable barrier that sieves the filtrate, retarding larger molecules such as proteins from leaving the blood stream. As all blood vessels allow a degree of protein leak , true equilibrium across the membrane cannot occur and there is a continuous flow of water with small solutes. The molecular sieving properties of the capillary wall reside in a recently discovered endocapillary layer rather than in the dimensions of pores through or between the endothelial cells.[1] This fibre matrix endocapillary layer is called the endothelial glycocalyx.The Starling equation describes that relationship in mathematical form and can be applied to many biological and non-biological semipermeable membranes.

  1. ^ Curry, F. E.; Michel, C. C. (1980-07-01). "A fiber matrix model of capillary permeability". Microvascular Research. 20 (1): 96–99. doi:10.1016/0026-2862(80)90024-2. ISSN 0026-2862. PMID 7412590.
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