Cavernous hemangioma
| Cavernous hemangioma | |
|---|---|
| Micrograph of a cavernous liver hemangioma. H&E stain. | |
| Specialty | Oncology, hematology, cardiology, neurosurgery |
Cavernous hemangioma, also called cavernous angioma, venous malformation, or cavernoma,[1][2] is a type of venous malformation due to endothelial dysmorphogenesis from a lesion which is present at birth. A cavernoma in the brain is called a cerebral cavernous malformation or CCM. Despite its designation as a hemangioma, a cavernous hemangioma is a benign (but not harmless) condition, not a malignant tumor, as it does not display endothelial hyperplasia. The abnormal tissue causes a slowing of blood flow through the cavities, or "caverns". The blood vessels do not form the necessary junctions with surrounding cells, and the structural support from the smooth muscle is hindered, causing leakage into the surrounding tissue. It is the leakage of blood (hemorrhage) that causes a variety of symptoms known to be associated with the condition.
- ^ Awad IA, Polster SP (July 2019). "Cavernous angiomas: deconstructing a neurosurgical disease". Journal of Neurosurgery. 131 (1): 1–13. doi:10.3171/2019.3.JNS181724. PMC 6778695. PMID 31261134.
- ^ Algra A, Rinkel GJ (February 2016). "Prognosis of cerebral cavernomas: on to treatment decisions". The Lancet. Neurology. 15 (2): 129–130. doi:10.1016/S1474-4422(15)00340-3. PMID 26654286.