Childhood cancer

Childhood cancer
Other namesPediatric cancer
A girl trying out hats to wear after chemotherapy against a Wilms' tumor[1]
SpecialtyPediatrics, oncology

Childhood cancer is cancer in a child. About 80% of childhood cancer cases in high-income countries can be treated with modern treatments and good medical care.[2][3] Yet, only 10% of children with cancer live in high-income countries where proper treatment and care are available.[4][5] Children with cancer make up only about 1% of all cancer cases diagnosed globally each year.[6] The majority of children with cancer are in low- and middle-income countries, where it is responsible for 94% of deaths among those under 15 years old.[7] Because new cancer treatments are not easily available in these countries.[7] For this reason, in low and mid-income countries, childhood cancer is often ignored in control planning, contributing to the burden of missed opportunities for its diagnoses and management.[8]

Despite having better care, childhood cancer survivors are still at risk of recurrence and primary cancers.[9] They also face challenges in education, income, and social support compared to the general population and their siblings.[10]

In the United States, an arbitrarily adopted standard of the ages used is 0–14 years inclusive, up to age 14 years 11.9 months.[11][12] However, the definition of childhood cancer sometimes includes adolescents between 15 and 19 years old.[12] Pediatric oncology is the branch of medicine concerned with the diagnosis and treatment of cancer in children.

  1. ^ "Wilms tumor" – via Mount Sinai Hospital, New York.
  2. ^ Botta L, Gatta G, Capocaccia R, Stiller C, Cañete A, Dal Maso L, et al. (December 2022). "Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study". The Lancet. Oncology. 23 (12): 1525–1536. doi:10.1016/s1470-2045(22)00637-4. PMID 36400102. S2CID 253602412.
  3. ^ Moskalewicz A, Martinez B, Uleryk EM, Pechlivanoglou P, Gupta S, Nathan PC (2024-01-25). "Late mortality among 5-year survivors of childhood cancer: A systematic review and meta-analysis". Cancer. 130 (10): 1844–1857. doi:10.1002/cncr.35213. ISSN 0008-543X. PMID 38271115.
  4. ^ Rodriguez-Galindo C, Friedrich P, Alcasabas P, Antillon F, Banavali S, Castillo L, et al. (September 2015). "Toward the Cure of All Children With Cancer Through Collaborative Efforts: Pediatric Oncology As a Global Challenge". Journal of Clinical Oncology. 33 (27): 3065–3073. doi:10.1200/JCO.2014.60.6376. PMC 4979198. PMID 26304881.
  5. ^ "Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995". PsycEXTRA Dataset. 1999. doi:10.1037/e407432005-001.
  6. ^ Bhakta N, Force LM, Allemani C, Atun R, Bray F, Coleman MP, et al. (January 2019). "Childhood cancer burden: a review of global estimates" (PDF). The Lancet. Oncology. 20 (1): e42 – e53. doi:10.1016/S1470-2045(18)30761-7. ISSN 1474-5488. PMID 30614477.
  7. ^ a b Iniesta RR, Paciarotti I, Brougham MF, McKenzie JM, Wilson DC (May 2015). "Effects of pediatric cancer and its treatment on nutritional status: a systematic review". Nutrition Reviews. 73 (5): 276–295. doi:10.1093/nutrit/nuu062. ISSN 1753-4887. PMID 26011902.
  8. ^ Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E (April 2021). "Childhood cancer: Estimating regional and global incidence". Cancer Epidemiology. Childhood Cancer: A Global Perspective. 71 (Pt B): 101662. doi:10.1016/j.canep.2019.101662. PMID 31924557. S2CID 210150574.
  9. ^ Wu Y, Deng Y, Wei B, Xiang D, Hu J, Zhao P, et al. (September 2022). "Global, regional, and national childhood cancer burden, 1990–2019: An analysis based on the Global Burden of Disease Study 2019". Journal of Advanced Research. 40: 233–247. doi:10.1016/j.jare.2022.06.001. PMC 9481947. PMID 35700919.
  10. ^ Frederiksen LE, Mader L, Feychting M, Mogensen H, Madanat-Harjuoja L, Malila N, et al. (2019-04-15). "Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes". International Journal of Cancer. 144 (8): 1796–1823. doi:10.1002/ijc.31789. ISSN 0020-7136. PMID 30098012.
  11. ^ Bahadur G, Hindmarsh P (January 2000). "Age definitions, childhood and adolescent cancers in relation to reproductive issues". Human Reproduction. 15 (1): 227. doi:10.1093/humrep/15.1.227. PMID 10611218.
  12. ^ a b "Childhood Cancers: Basic Facts & Figures". Minnesota Department of Health. Archived from the original on 20 September 2017. Retrieved 1 December 2012.