Estradiol valerate/hydroxyprogesterone caproate
Estradiol valerate (top) and hydroxyprogesterone caproate (bottom) | |
| Combination of | |
|---|---|
| Estradiol valerate | Estrogen |
| Hydroxyprogesterone caproate | Progestogen |
| Clinical data | |
| Trade names | Gravibinon, Injectable No. 1, others |
| Other names | EV/OHPC; NSC-77622 |
| Routes of administration | Intramuscular injection |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| UNII | |
Estradiol valerate/hydroxyprogesterone caproate (EV/OHPC), sold under the brand names Gravibinon and Injectable No. 1 (or Chinese Injectable No. 1) among others, is a combined estrogen and progestogen medication which is used in the treatment of threatened miscarriage and other indications (e.g., as a means of pseudopregnancy)[1][2][3] and as a form of combined injectable birth control to prevent pregnancy.[4][5][6] It contains estradiol valerate (EV), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin.[7][4][5] The medication is given by injection into muscle once a day to once a month depending on the indication.[1][4][5]
- ^ a b Göretzlehner G, Lauritzen C, Göretzlehner U (1 January 2007). "Störungen des Menstrual Zyklus und ihre Therapie". Praktische Hormontherapie in der Gynäkologie. Walter de Gruyter. pp. 117, 337, 385, 391–392. ISBN 978-3-11-020864-1.
- ^ Schindler AE (June 2001). "[Treatment of high risk pregnancy with gravibinon]". Zentralblatt für Gynäkologie. 123 (6): 353–356. doi:10.1055/s-2001-16285. PMID 11488163. S2CID 71374491.
- ^ Cite error: The named reference
pmid15106366was invoked but never defined (see the help page). - ^ a b c Garza-Flores J (April 1994). "Pharmacokinetics of once-a-month injectable contraceptives". Contraception. 49 (4): 347–359. doi:10.1016/0010-7824(94)90032-9. PMID 8013219.
- ^ a b c Sang GW (April 1994). "Pharmacodynamic effects of once-a-month combined injectable contraceptives". Contraception. 49 (4): 361–385. doi:10.1016/0010-7824(94)90033-7. PMID 8013220.
- ^ Cite error: The named reference
pmid8013216was invoked but never defined (see the help page). - ^ Muller (19 June 1998). European Drug Index: European Drug Registrations (Fourth ed.). CRC Press. pp. 561–. ISBN 978-3-7692-2114-5.