Chlorambucil
| Clinical data | |
|---|---|
| Trade names | Leukeran, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682899 |
| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Liver |
| Elimination half-life | 1.5 hours |
| Excretion | N/A |
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| ECHA InfoCard | 100.005.603 |
| Chemical and physical data | |
| Formula | C14H19Cl2NO2 |
| Molar mass | 304.21 g·mol−1 |
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Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma.[1] For CLL it is a preferred treatment.[2] It is given by mouth.[2]
Common side effects include bone marrow suppression.[2] Other serious side effects include an increased long term risk of further cancer, infertility, and allergic reactions.[2] Use during pregnancy often results in harm to the baby.[2] Chlorambucil is in the alkylating agent family of medications.[2] It works by blocking the formation of DNA and RNA.[2]
Chlorambucil was approved for medical use in the United States in 1957.[2] It is on the World Health Organization's List of Essential Medicines.[3][4] It was originally made from nitrogen mustard.[2]
- ^ "Chlorambucil". National Cancer Institute. 17 September 2014. Archived from the original on 21 December 2016. Retrieved 19 December 2016.
- ^ a b c d e f g h i "Chlorambucil". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.