Chlordane

Chlordane
cis-chlordane (α-chlordane)	trans-chlordane (γ-chlordane, beta-chlordane)
cis-chlordane	trans-chlordane
Names
	Systematic IUPAC name 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
	Other names Chlordan; Chlordano; Ortho; Octachloro-4,7-methanohydroindane
Identifiers
CAS Number	57-74-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:34623;
ChemSpider	5772;
ECHA InfoCard	100.000.317
EC Number	200-349-0;
IUPHAR/BPS	2831;
KEGG	C14176 ;
PubChem CID	5993;
UNII	A9RLM212CY ;
UN number	2996 2762
CompTox Dashboard (EPA)	DTXSID7020267 ;
	InChI InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2 Key: BIWJNBZANLAXMG-UHFFFAOYSA-N;
	SMILES C1C2C(C(C1Cl)Cl)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl;
Properties
Chemical formula	C10H6Cl8
Molar mass	409.76 g·mol−1
Appearance	White solid
Odor	Slightly pungent, chlorine-like
Density	1.59 g/cm3
Melting point	102–106 °C (216–223 °F; 375–379 K)
Boiling point	decomposes
Solubility in water	0.0001% (20°C)
Refractive index (nD)	1.565
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	moderately toxic and a suspected human carcinogen
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H301, H311, H351, H410
Precautionary statements	P201, P273, P280, P301+P310+P330, P302+P352+P312
Flash point	107 °C (225 °F; 380 K) (open cup)
Explosive limits	0.7–5%
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	590 mg/kg (rat, oral); 100 mg/kg (rabbit, oral); 430 mg/kg (mouse, oral); 300 mg/kg (rabbit, oral); 145 mg/kg (mouse, oral); 1720 mg/kg (hamster, oral); 200 mg/kg (rat, oral)
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.5 mg/m3 [skin]
REL (Recommended)	Ca TWA 0.5 mg/m3 [skin]
IDLH (Immediate danger)	100 mg/m3
Safety data sheet (SDS)	Chlordane (technical mixture)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Chlordane, or chlordan, is an organochlorine compound that was used as a pesticide. It is a white solid. In the United States, chlordane was used for termite-treatment of approximately 30 million homes until it was banned in 1988.^[4] Chlordane was banned 10 years earlier for food crops like corn and citrus, and on lawns and domestic gardens.^[5]

Like other chlorinated cyclodiene insecticides, chlordane is classified as an organic pollutant hazardous for human health. It is resistant to degradation in the environment and in humans/animals and readily accumulates in lipids (fats) of humans and animals.^[6] Exposure to the compound has been linked to cancers, diabetes, and neurological disorders.

^ ^a ^b ^c ^d ^e ^f NIOSH Pocket Guide to Chemical Hazards. "#0112". National Institute for Occupational Safety and Health (NIOSH).
^ Sigma-Aldrich Co., Chlordane (technical mixture). Retrieved on 2022-03-17.
^ "Chlordane". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
^ Toxicological Profile for Chlordane, U.S. Department Of Health and Human Services, Agency for Toxic Substances and Disease Registry
^ Robert L. Metcalf "Insect Control" in Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2002. doi:10.1002/14356007.a14_263
^ Agency for Toxic Substances & Disease Registry (ATSDR). Toxic Substances Portal: Chlordane. Last updated September, 2010 [online]. Available at URL: https://wwwn.cdc.gov/TSP/index.aspx?toxid=62

[PGCH-1] ^ ^a ^b ^c ^d ^e ^f NIOSH Pocket Guide to Chemical Hazards. "#0112". National Institute for Occupational Safety and Health (NIOSH).

[sigma-2] Sigma-Aldrich Co., Chlordane (technical mixture). Retrieved on 2022-03-17.

[3] "Chlordane". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).

[4] Toxicological Profile for Chlordane, U.S. Department Of Health and Human Services, Agency for Toxic Substances and Disease Registry

[Ullmann-5] Robert L. Metcalf "Insect Control" in Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2002. doi:10.1002/14356007.a14_263

[ATSDR_2010-6] Agency for Toxic Substances & Disease Registry (ATSDR). Toxic Substances Portal: Chlordane. Last updated September, 2010 [online]. Available at URL: https://wwwn.cdc.gov/TSP/index.aspx?toxid=62

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