Cholera toxin

Cholera toxin Subunit B
Cholera toxin Subunit B
	3D structure of cholera toxin subunit B. (top view with CTA subunit removed)
Identifiers
Symbol	ctxB
CAS number	9012-63-9
NCBI gene	944741
PDB	1CHP
RefSeq	WP_000987577.1
UniProt	P01556
Other data
EC number	2.4.2.36
Wikidata	Q189245
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

Cholera toxin Subunit A
Cholera toxin Subunit A
Identifiers
Symbol	ctxA
CAS number	9012-63-9
NCBI gene	944742
PDB	1S5B
RefSeq	WP_001889387.1
UniProt	P01555
Other data
EC number	2.4.2.36
Wikidata	Q189245
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Cholera toxin (also known as choleragen, CTX, CTx and CT) is a potent enterotoxin produced by the bacterium Vibrio cholerae which causes severe watery diarrhea and dehydration that define cholera infections. The toxin is a member of the heat-labile enterotoxin family, and exists as an AB5 multimeric toxin with one enzymatically active A subunit and five receptor-binding B subunits that facilitate host cell entry.^[1]^[2]

^ Serrano A, Guyette JL, Heim JB, Taylor M, Cherubin P, Krengel U, et al. (2022-01-07). "Holotoxin disassembly by protein disulfide isomerase is less efficient for Escherichia coli heat-labile enterotoxin than cholera toxin". Scientific Reports. 12 (1): 34. Bibcode:2022NatSR..12...34S. doi:10.1038/s41598-021-03939-9. ISSN 2045-2322. PMC 8741891. PMID 34997016.
^ Safa A, Jime JS, Shahel F (2020). "Cholera toxin phage: structural and functional diversity between Vibrio cholerae biotypes". AIMS Microbiology. 6 (2): 144–151. doi:10.3934/microbiol.2020009. ISSN 2471-1888. PMC 7326730. PMID 32617446.

[:5-1] Serrano A, Guyette JL, Heim JB, Taylor M, Cherubin P, Krengel U, et al. (2022-01-07). "Holotoxin disassembly by protein disulfide isomerase is less efficient for Escherichia coli heat-labile enterotoxin than cholera toxin". Scientific Reports. 12 (1): 34. Bibcode:2022NatSR..12...34S. doi:10.1038/s41598-021-03939-9. ISSN 2045-2322. PMC 8741891. PMID 34997016.

[:02-2] Safa A, Jime JS, Shahel F (2020). "Cholera toxin phage: structural and functional diversity between Vibrio cholerae biotypes". AIMS Microbiology. 6 (2): 144–151. doi:10.3934/microbiol.2020009. ISSN 2471-1888. PMC 7326730. PMID 32617446.

[1]

[2]