Cilastatin

Not to be confused with HMG-CoA reductase inhibitors, commonly referred to as statins.
Cilastatin
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa686013
Routes of
administration		IV
ATC code
Identifiers
IUPAC name
  • (Z)-7-[(2R)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.072.592
Chemical and physical data
FormulaC16H26N2O5S
Molar mass358.45 g·mol−1
3D model (JSmol)
SMILES
  • O=C(N\C(=C/CCCCSC[C@@H](C(=O)O)N)C(=O)O)[C@H]1CC1(C)C
InChI
  • InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1 Y
  • Key:DHSUYTOATWAVLW-WFVMDLQDSA-N Y
  (verify)

Cilastatin inhibits the human enzyme dehydropeptidase.[1]

  1. ^ Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ (1995). "The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA". Antimicrob. Agents Chemother. 39 (7): 1629–31. doi:10.1128/aac.39.7.1629. PMC 162797. PMID 7492120.
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