Collective cell migration

Collective cell migration describes the movements of group of cells and the emergence of collective behavior from cell-environment interactions and cell-cell communication. Collective cell migration is an essential process in the lives of multicellular organisms, e.g. embryonic development, wound healing and cancer spreading (metastasis).[1] Cells can migrate as a cohesive group (e.g. epithelial cells) or have transient cell-cell adhesion sites (e.g. mesenchymal cells).[2] They can also migrate in different modes like sheets, strands, tubes, and clusters.[3] While single-cell migration has been extensively studied, collective cell migration is a relatively new field with applications in preventing birth defects or dysfunction of embryos. It may improve cancer treatment by enabling doctors to prevent tumors from spreading and forming new tumors.

  1. ^ Friedl, P; Hegerfeldt, Y; Tusch, M (2004). "Collective cell migration in morphogenesis and cancer". The International Journal of Developmental Biology. 48 (5–6): 441–9. doi:10.1387/ijdb.041821pf. PMID 15349818.
  2. ^ Weijer, CJ (15 September 2009). "Collective cell migration in development". Journal of Cell Science. 122 (Pt 18): 3215–23. doi:10.1242/jcs.036517. PMID 19726631.
  3. ^ Friedl, P (February 2004). "Prespecification and plasticity: shifting mechanisms of cell migration". Current Opinion in Cell Biology. 16 (1): 14–23. doi:10.1016/j.ceb.2003.11.001. PMID 15037300.
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