Copenhagen disease

Copenhagen disease
Other namesProgressive non-infectious anterior vertebral fusion, Copenhagen syndrome
SpecialtyOrthopedic
CausesUnknown
Diagnostic methodX-ray, MRI

Copenhagen disease, sometimes known as Copenhagen syndrome or progressive non-infectious anterior vertebral fusion (PAVF), is a very rare childhood spinal disorder of unknown cause, with distinctive radiological features. It is characterized by the progressive fusion of the anterior vertebral body in the thoracolumbar region of the spine.[1]

It was first identified in 1949[2] and 80–100 reported cases since, 60% of which were female.[3] Due to the disease's rarity, research into this condition has been limited.[4]

Copenhagen disease is known as such because the majority of cases were found at Copenhagen University Hospital.[5][6]

  1. ^ Meurisse F, Irani MJ, Davies RJ (April 2001). "MRI of Copenhagen's disease in an adult". Clinical Radiology. 56 (4): 335–7. doi:10.1053/crad.1999.0176. PMID 11286590.
  2. ^ Knutsson F (December 1949). "Fusion of vertebrae following non-infectious disturbance in the zone of growth". Acta Radiologica. 32 (5–6): 404–6, illust. doi:10.3109/00016924909140003. PMID 15402751.
  3. ^ Hughes RJ, Saifuddin A (June 2006). "Progressive non-infectious anterior vertebral fusion (Copenhagen Syndrome) in three children: features on radiographs and MR imaging". Skeletal Radiology. 35 (6): 397–401. doi:10.1007/s00256-005-0033-9. PMID 16328382. S2CID 28254365.
  4. ^ Malagelada, Francesc; Sewell, Mathew D.; Fahmy, Amr; Gibson, Alexander (2015-04-01). "Long-term clinical and radiological outcomes of Copenhagen syndrome with 19 affected levels: a case report". The Spine Journal. 15 (4): e19 – e23. doi:10.1016/j.spinee.2014.12.005. ISSN 1529-9430.
  5. ^ Cite error: The named reference JBJS1991 was invoked but never defined (see the help page).
  6. ^ Stoker D (January 2002). "Progressive non-infectious anterior vertebral fusion ('Copenhagen disease')". Clinical Radiology. 57 (1): 76. doi:10.1053/crad.2001.0809. PMID 11858144.
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