Denervation

Denervation is any loss of nerve supply regardless of the cause. If the nerves lost to denervation are part of neural communication to an organ system or for a specific tissue function, alterations to or compromise of physiological functioning can occur.[1] Denervation can result from an injury or be a symptom of a disorder like amyotrophic lateral sclerosis (ALS),[2] post-polio syndrome,[3] or neuropathic postural orthostatic tachycardia syndrome (POTS).[4][5] Intentional denervation is a valuable surgical technique for managing some medical conditions, such as renal denervation in the setting of uncontrolled hypertension.[6] Pathological denervation, by contrast, is associated with serious health sequelae, including increased infection susceptibility and tissue dysfunction.[7]

  1. ^ Forster, H. V. (2003-02-01). "Invited Review: Plasticity in the control of breathing following sensory denervation". Journal of Applied Physiology. 94 (2): 784–794. doi:10.1152/japplphysiol.00602.2002. ISSN 8750-7587. PMID 12531915.
  2. ^ Kwan, Thaddaeus; Kazamel, Mohamed; Thoenes, Kristina; Si, Ying; Jiang, Nan; King, Peter H. (2020-10-07). "Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis". Scientific Reports. 10 (1): 16679. doi:10.1038/s41598-020-73845-z. ISSN 2045-2322. PMC 7541525. PMID 33028902. S2CID 222209385.
  3. ^ Jubelt, B.; Cashman, N. R. (1987). "Neurological manifestations of the post-polio syndrome". Critical Reviews in Neurobiology. 3 (3): 199–220. ISSN 0892-0915. PMID 3315237.
  4. ^ Lei, Lucy Y.; Chew, Derek S.; Sheldon, Robert S.; Raj, Satish R. (2019-05-01). "Evaluating and managing postural tachycardia syndrome". Cleveland Clinic Journal of Medicine. 86 (5): 333–344. doi:10.3949/ccjm.86a.18002. ISSN 0891-1150. PMID 31066664. S2CID 147705420.
  5. ^ Haensch, Carl-Albrecht; Tosch, Marco; Katona, Istvan; Weis, Joachim; Isenmann, Stefan (December 2014). "Small-fiber neuropathy with cardiac denervation in postural tachycardia syndrome". Muscle & Nerve. 50 (6): 956–961. doi:10.1002/mus.24245. ISSN 1097-4598. PMID 24647968. S2CID 3301605.
  6. ^ Rey-García, Jimena; Townsend, Raymond R. (October 2022). "Renal Denervation: A Review". American Journal of Kidney Diseases. 80 (4): 527–535. doi:10.1053/j.ajkd.2022.03.015. ISSN 0272-6386. Archived from the original on 2022-12-28.
  7. ^ Quinn, M. J. (2011-11-01). "Origins of Western diseases". Journal of the Royal Society of Medicine. 104 (11): 449–456. doi:10.1258/jrsm.2011.110014. ISSN 0141-0768. PMC 3206721. PMID 22048676.
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