Dermatan sulfate

Dermatan sulfate
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	B01AX04 (WHO) ;
Identifiers
CAS Number	24967-94-0 ;
ChemSpider	none;
UNII	J3OC7JVS54;
CompTox Dashboard (EPA)	DTXSID40179683 ;
ECHA InfoCard	100.042.305
Chemical and physical data
Formula	C14H21NO15S
Molar mass	475.37 g·mol−1
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Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.

It is also referred to as chondroitin sulfate B,^[1] although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C₁₄H₂₁NO₁₅S. This carbohydrate is composed of linear polymers of disaccharide units that contain, N-acetyl galactosamine (GalNAc) and iduronic acid (IdoA). These repeating units are sulfated at a variety of positions.^[2] Dermatan sulfate is a component of the compound sulodexide.^[3]

^ Trowbridge JM, Gallo RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology. 12 (9): 117R – 125R. doi:10.1093/glycob/cwf066. PMID 12213784.
^ "Dermatan sulfate".
^ Lasierra-Cirujeda J, Coronel P, Aza M, Gimeno M (2010). "Use of sulodexide in patients with peripheral vascular disease". Journal of Blood Medicine. 1: 105–115. doi:10.2147/JBM.S10558. PMC 3262318. PMID 22282689. Sulodexide is a highly purified glycosaminoglycan (GAG) obtained from porcine digestive mucosa and is composed of a mixture of 80% heparan sulfate (an electrophoretically fast moving fraction with a low molecular weight of 7000 Da and affinity for antithrombin III) and 20% dermatan sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor.

[Trowbridge_2002-1] Trowbridge JM, Gallo RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology. 12 (9): 117R – 125R. doi:10.1093/glycob/cwf066. PMID 12213784.

[2] "Dermatan sulfate".

[Lasierra-Cirujeda_2010-3] Lasierra-Cirujeda J, Coronel P, Aza M, Gimeno M (2010). "Use of sulodexide in patients with peripheral vascular disease". Journal of Blood Medicine. 1: 105–115. doi:10.2147/JBM.S10558. PMC 3262318. PMID 22282689. Sulodexide is a highly purified glycosaminoglycan (GAG) obtained from porcine digestive mucosa and is composed of a mixture of 80% heparan sulfate (an electrophoretically fast moving fraction with a low molecular weight of 7000 Da and affinity for antithrombin III) and 20% dermatan sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor.

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