Developmental origins of health and disease
Developmental origins of health and disease (DOHaD) is an approach to medical research factors that can lead to the development of human diseases during early life development. These factors include the role of prenatal and perinatal exposure to environmental factors, such as undernutrition, stress, environmental chemical, etc.[1][2] This approach includes an emphasis on epigenetic causes of adult chronic non-communicable diseases.[1][3][4] As well as physical human disease, the psychopathology of the foetus can also be predicted by epigenetic factors.[5]
- ^ a b Wadhwa PD, Buss C, Entringer S, Swanson JM (September 2009). "Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms". Seminars in Reproductive Medicine. 27 (5): 358–368. doi:10.1055/s-0029-1237424. PMC 2862635. PMID 19711246.
- ^ Gillman MW (October 2005). "Developmental origins of health and disease". The New England Journal of Medicine. 353 (17): 1848–1850. doi:10.1056/NEJMe058187. PMC 1488726. PMID 16251542.
- ^ Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA (May 2007). "Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease". Pediatric Research. 61 (5 Pt 2): 5R – 10R. doi:10.1203/pdr.0b013e318045bedb. PMID 17413851.
- ^ Heindel JJ, Balbus J, Birnbaum L, Brune-Drisse MN, Grandjean P, Gray K, et al. (October 2015). "Developmental Origins of Health and Disease: Integrating Environmental Influences". Endocrinology. 156 (10): 3416–3421. doi:10.1210/EN.2015-1394. PMC 4588819. PMID 26241070.
- ^ O'Donnell KJ, Meaney MJ (April 2017). "Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis". The American Journal of Psychiatry. 174 (4): 319–328. doi:10.1176/appi.ajp.2016.16020138. PMID 27838934.