1,2-Diarylethylamine
| 1,2-Diarylethylamine | |
|---|---|
| Drug class | |
1,2-Diphenylethylamine, the parent structure of most of the 1,2-diarylethylamines | |
| Class identifiers | |
| Synonyms | 1,2-Diphenylethylamines |
| Use | Research chemicals; some as designer drugs |
| Mode of action | Dissociative |
| Mechanism of action | Antagonist |
| Biological target | NMDA receptor |
| Chemical class | Arylalkylamine |
| Legal status | |
| In Wikidata | |
1,2-Diarylethylamines are a class of psychoactive compounds defined by two aryl groups attached to adjacent carbon atoms on an ethylamine backbone.[1] These compounds display a range of pharmacological activities, most notably as NMDA receptor antagonists, and have attracted attention as dissociative designer drugs that produce feelings of detachment from reality or oneself.[2]
- ^ Wallach J, Brandt SD (2018). "1,2-Diarylethylamine-and Ketamine-Based New Psychoactive Substances.". In Maurer H, Brandt S (eds.). New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 305–352. doi:10.1007/164_2018_148. ISBN 978-3-030-10560-0. PMID 30196446.
- ^ Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, et al. (2016). "Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues". PLOS ONE. 11 (6): e0157021. Bibcode:2016PLoSO..1157021W. doi:10.1371/journal.pone.0157021. PMC 4912077. PMID 27314670.