Diclofenac/misoprostol
| Combination of | |
|---|---|
| Diclofenac | NSAID |
| Misoprostol | Prostaglandin analog |
| Clinical data | |
| Trade names | Arthrotec |
| MedlinePlus | a699002 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
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| Identifiers | |
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| (verify) | |
Diclofenac/misoprostol, sold under the brand name Arthrotec, is a fixed-dose combination medication that contains:
- Diclofenac sodium: Nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties
- Misoprostol: Gastrointestinal (GI) mucosal protective prostaglandin E1 analog.
In the United Kingdom it is marketed by Pharmacia and it is indicated for prophylaxis against NSAID-induced gastroduodenal ulceration in people requiring diclofenac for rheumatoid arthritis or osteoarthritis.[2]
The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy.[4]
- ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
- ^ a b "Arthrotec 50 modified-release Tablets - Summary of Product Characteristics (SmPC)". (emc). 17 March 2021. Retrieved 3 August 2021.
- ^ "Arthrotec- diclofenac sodium and misoprostol tablet, film coated". DailyMed. Retrieved 3 August 2021.
- ^ Plosker GL, Lamb HM (July 1999). "Diclofenac/misoprostol. Pharmacoeconomic implications of therapy". PharmacoEconomics. 16 (1): 85–98. doi:10.2165/00019053-199916010-00008. PMID 10539124. S2CID 209146468.