Dicycloverine

Dicycloverine
Clinical data
Trade names	Byclomine, Bentyl, Dibent, others
AHFS/Drugs.com	Monograph
MedlinePlus	a684007
License data	US DailyMed: Dicyclomine;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth, intramuscular
Drug class	Antimuscarinic
ATC code	A03AA07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	>99%
Elimination half-life	5 hours
Identifiers
	IUPAC name 2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;
CAS Number	77-19-0 ;
PubChem CID	3042;
IUPHAR/BPS	355;
DrugBank	DB00804 ;
ChemSpider	2934 ;
UNII	4KV4X8IF6V;
KEGG	D07820 ;
ChEBI	CHEBI:4514 ;
ChEMBL	ChEMBL1123 ;
CompTox Dashboard (EPA)	DTXSID1022926 ;
ECHA InfoCard	100.000.919
Chemical and physical data
Formula	C19H35NO2
Molar mass	309.494 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCN(CC)CC)C1(CCCCC1)C2CCCCC2;
	InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 ; Key:CURUTKGFNZGFSE-UHFFFAOYSA-N ;
	(verify)

Dicycloverine, also known as dicyclomine, sold under the brand name Bentyl among others, is a medication that is used to treat spasms of the intestines such as those that occur in irritable bowel syndrome (IBS).^[1]^[2] It is taken by mouth or by injection into a muscle.^[2] While it has been used in baby colic and enterocolitis, evidence does not support these uses.^[2]

Common side effects include dry mouth, blurred vision, weakness, sleepiness, and lightheadedness.^[2] Serious side effects may include psychosis and breathing problems in babies.^[2] Use in pregnancy appears to be safe while use during breastfeeding is not recommended.^[3] How it works is not entirely clear.^[2]

Dicycloverine was approved for medical use in the United States in 1950.^[2] It is available as a generic medication.^[1] In 2022, it was the 176th most commonly prescribed medication in the United States, with more than 2 million prescriptions.^[4]^[5]

^ ^a ^b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 759. ISBN 9780857113382.
^ ^a ^b ^c ^d ^e ^f ^g "Dicyclomine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ "Dicyclomine Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
^ "Dicyclomine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

[BNF76-1] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 759. ISBN 9780857113382.

[AHFS2019-2] ^ ^a ^b ^c ^d ^e ^f ^g "Dicyclomine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-3] "Dicyclomine Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[4] "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.

[5] "Dicyclomine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

[1]

[2]

[3]

[4]

[5]