Diphenoxylate

Diphenoxylate
Clinical data
Other names	R-1132, NIH-756
AHFS/Drugs.com	Monograph
Routes of; administration	Oral
Drug class	Opioid ; Antidiarrheal
ATC code	A07DA01 (WHO) ;
Legal status
Legal status	AU: S3 (OTC, packs of up to 8x tablets combined with Atropine) & S4 (Rx Only, as S3 but larger pack sizes) & S8 (Controlled, all other preparations); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Prescription only (Anlage II for higher doses) if combined with atropine sulphate; UK: Class A; US: Schedule II (alone) and V (with atropine);
Pharmacokinetic data
Protein binding	74–95%
Elimination half-life	12–14 hours
Identifiers
	IUPAC name ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate;
CAS Number	915-30-0 ;
PubChem CID	13505;
IUPHAR/BPS	7164;
DrugBank	DB01081 ;
ChemSpider	12919 ;
UNII	73312P173G;
KEGG	D07861 ;
ChEBI	CHEBI:4639 ;
ChEMBL	ChEMBL1201294 ;
CompTox Dashboard (EPA)	DTXSID8022951 ;
ECHA InfoCard	100.011.837
Chemical and physical data
Formula	C30H32N2O2
Molar mass	452.598 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#CC(c1ccccc1)(c2ccccc2)CCN4CCC(c3ccccc3)(C(=O)OCC)CC4;
	InChI InChI=1S/C30H32N2O2/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27/h3-17H,2,18-23H2,1H3 ; Key:HYPPXZBJBPSRLK-UHFFFAOYSA-N ;
	(what is this?) (verify)

Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridioides difficile infection.

^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.