Dobutamine

Dobutamine
Clinical data
Trade names	Dobutrex, Inotrex, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682861
License data	US DailyMed: Dobutamine;
Pregnancy; category	AU: B2;
Routes of; administration	Intravenous, intraosseous
Drug class	β1-agonist
ATC code	C01CA07 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Onset of action	Within 2 min
Elimination half-life	2 minutes
Identifiers
	IUPAC name (RS)-4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol;
CAS Number	34368-04-2 ; HCl: 49745-95-1 ;
PubChem CID	36811;
IUPHAR/BPS	535;
DrugBank	DB00841 ;
ChemSpider	33786 ;
UNII	3S12J47372; HCl: 0WR771DJXV ;
KEGG	D03879 ;
ChEBI	CHEBI:4670 ;
ChEMBL	ChEMBL926 ;
CompTox Dashboard (EPA)	DTXSID3022958 ;
Chemical and physical data
Formula	C18H23NO3
Molar mass	301.386 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES Oc1ccc(cc1O)CCNC(C)CCc2ccc(O)cc2;
	InChI InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3 ; Key:JRWZLRBJNMZMFE-UHFFFAOYSA-N ;
	(verify)

Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure.^[2]^[3] It may also be used in certain types of cardiac stress tests.^[2] It is given by IV only, as an injection into a vein or intraosseous as a continuous infusion.^[2] The amount of medication needs to be adjusted to the desired effect.^[2] Onset of effects is generally seen within 2 minutes.^[2] It has a half-life of two minutes. This drug is generally only administered short term, although it may be used for longer periods to relieve symptoms of heart failure in patients awaiting heart transplantation.^[4]

Common side effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection.^[2]^[5] Use is not recommended in those with idiopathic hypertrophic subaortic stenosis.^[2] It primarily works by direct stimulation of β₁ receptors, which increases the strength of the heart's contractions, leading to a positive inotropic effect. Generally it has little effect on a person's heart rate.^[2]

Dobutamine was approved for medical use in the United States in 1978.^[2] It is available as a generic medication.^[5] It was initially made from isoproterenol.^[3]

^ ^a ^b "Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Dobutamine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 11 January 2019.
^ ^a ^b Wilson WC, Grande CM, Hoyt DB (2007). Trauma: Critical Care. CRC Press. p. 302. ISBN 978-1-4200-1684-0.
^ Gentile P, Marini C, Ammirati E, Perna E, Saponara G, Garascia A, et al. (October 2021). "Long-term administration of intravenous inotropes in advanced heart failure". ESC Heart Failure. 8 (5): 4322–4327. doi:10.1002/ehf2.13394. PMC 8497373. PMID 34191408.
^ ^a ^b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 220–221. ISBN 978-0-85711-338-2.

[Drugs.com_pregnancy-1] "Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020.

[AHFS2019-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Dobutamine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 11 January 2019.

[Wil2007-3] Wilson WC, Grande CM, Hoyt DB (2007). Trauma: Critical Care. CRC Press. p. 302. ISBN 978-1-4200-1684-0.

[4] Gentile P, Marini C, Ammirati E, Perna E, Saponara G, Garascia A, et al. (October 2021). "Long-term administration of intravenous inotropes in advanced heart failure". ESC Heart Failure. 8 (5): 4322–4327. doi:10.1002/ehf2.13394. PMC 8497373. PMID 34191408.

[BNF76-5] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 220–221. ISBN 978-0-85711-338-2.

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