Docetaxel
| Clinical data | |
|---|---|
| Trade names | Taxotere, Docecad, Docefrez, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a696031 |
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| Routes of administration | Intravenous |
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| Bioavailability | NA |
| Protein binding | >98% |
| Metabolism | Liver |
| Elimination half-life | 11 hours |
| Excretion | Bile duct |
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| ECHA InfoCard | 100.129.246 |
| Chemical and physical data | |
| Formula | C43H53NO14 |
| Molar mass | 807.890 g·mol−1 |
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Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer.[5] This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer.[6] It may be used by itself or along with other chemotherapy medication.[5] It is given by slow injection into a vein.[5]
Common side effects include hair loss, cytopenia (low blood cell counts), numbness, shortness of breath, nausea, vomiting, and muscle pains.[5] Other severe side effects include allergic reactions and future cancers.[5] Docetaxel induced pneumotoxicity is also a well recognized adverse effect which has to be identified timely and treated after withholding the drug.[7] Side effects are more common in people with liver problems.[5] Use during pregnancy may harm the baby.[5] Docetaxel is in the taxane family of medications.[8] It works by disrupting the normal function of microtubules and thereby stopping cell division.[5]
Docetaxel was patented in 1986 and approved for medical use in 1995.[9] It is on the World Health Organization's List of Essential Medicines.[10] Docetaxel is available as a generic medication.[5]
- ^ "Docetaxel Use During Pregnancy". Drugs.com. 4 June 2020. Retrieved 29 October 2020.
- ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
- ^ "Taxotere- docetaxel injection, solution, concentrate". DailyMed. 26 December 2019. Retrieved 28 October 2020.
- ^ "Taxotere EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 28 October 2020.
- ^ a b c d e f g h i "Docetaxel". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- ^ "FDA Approval for Docetaxel". National Cancer Institute. 2006-10-05. Archived from the original on 21 December 2016. Retrieved 21 December 2016.
- ^ Hettiarachchi SM, Thilakaratne D, Dharmasena D, Rathnapala A, Abeysinghe P, Perera E (July 2021). "Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature". Respirology Case Reports. 9 (7): e00802. doi:10.1002/rcr2.802. PMC 8200505. PMID 34136263.
- ^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 622. ISBN 9780857111562.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 512. ISBN 9783527607495. Archived from the original on 2016-12-21.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.