Dopamine releasing agent

A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain.[1][2][3][4]

No selective DRAs are currently known.[5][6][7] However, non-selective DRAs, including norepinephrine–dopamine releasing agents (NDRAs) like amphetamine and methamphetamine, serotonin–norepinephrine–dopamine releasing agents (SNDRAs) like MDMA and mephedrone, and serotonin–dopamine releasing agents (SDRAs) like 5-chloro-αMT and BK-NM-AMT, are known.[8][9][10][7]

A closely related type of drug is a dopamine reuptake inhibitor (DRI).[11][12][13] In contrast to the case of DRAs, many selective DRIs are known.[11][12][13] Examples of selective DRIs include amineptine, modafinil, and vanoxerine.[11][12][13]

  1. ^ Blough B (July 2008). "Dopamine-releasing agents" (PDF). In Trudell ML, Izenwasser S (eds.). Dopamine Transporters: Chemistry, Biology and Pharmacology. Hoboken [NJ]: Wiley. pp. 305–320. ISBN 978-0-470-11790-3. OCLC 181862653. OL 18589888W.
  2. ^ Heal DJ, Smith SL, Gosden J, Nutt DJ (June 2013). "Amphetamine, past and present--a pharmacological and clinical perspective". Journal of Psychopharmacology. 27 (6): 479–496. doi:10.1177/0269881113482532. PMC 3666194. PMID 23539642.
  3. ^ Reith ME, Blough BE, Hong WC, Jones KT, Schmitt KC, Baumann MH, Partilla JS, Rothman RB, Katz JL (February 2015). "Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter". Drug and Alcohol Dependence. 147: 1–19. doi:10.1016/j.drugalcdep.2014.12.005. PMC 4297708. PMID 25548026. Article history: Received 6 November 2014 [...] A library of approximately 1400 phenethylamine compounds (PAL compounds) has been screened using these protocols.
  4. ^ Heal DJ, Gosden J, Smith SL (December 2014). "Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine". Neuropharmacology. 87: 19–40. doi:10.1016/j.neuropharm.2014.06.012. PMID 24953830.
  5. ^ Cite error: The named reference NegusMelloBlough2007 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference RothmanBloughBaumann2007 was invoked but never defined (see the help page).
  7. ^ a b Bauer CT (5 July 2014). Determinants of Abuse-Related Effects of Monoamine Releasers in Rats. VCU Scholars Compass (Thesis). doi:10.25772/AN08-SZ65. Retrieved 24 November 2024. Another potential determinant for increased abuse potential of [monoamine releasers (MARs)] is selectivity for [dopamine (DA)] versus [norepinephrine (NE)]. [...] amphetamine and other abused monoamine releasers have slightly (2 to 3x) higher potency to release NE than DA (Rothman et al., 2001). [...] ephedrine (a 19-fold NE-selective releaser) has been shown to maintain self-administration in monkeys (Anderson et al., 2001) and substitute for amphetamine (Young et al., 1998) and methamphetamine (Bondareva et al., 2002) in drug discrimination studies in rats. [...] This leads to the hypothesis that NE release is another determinant of the abuse-related effects produce by MARs; however, the role of DA vs. NE selectivity has been difficult to investigate further due to a lack of drugs that possess significant selectivity for DA or NE relative to the other catecholamine. [...] Unfortunately, compounds with low potency to release [serotonin (5HT)] and variable potencies to release DA vs. NE do not exist, [...]
  8. ^ Cite error: The named reference RothmanBaumann2003 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference RothmanBaumann2006 was invoked but never defined (see the help page).
  10. ^ Cite error: The named reference BloughLandavazoPartilla2014 was invoked but never defined (see the help page).
  11. ^ a b c Xue W, Fu T, Zheng G, Tu G, Zhang Y, Yang F, Tao L, Yao L, Zhu F (2020). "Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters". Curr Med Chem. 27 (23): 3830–3876. doi:10.2174/0929867325666181009123218. PMID 30306851.
  12. ^ a b c Nishino S, Kotorii N (2016). "Modes of Action of Drugs Related to Narcolepsy: Pharmacology of Wake-Promoting Compounds and Anticataplectics". Narcolepsy. Cham: Springer International Publishing. pp. 307–329. doi:10.1007/978-3-319-23739-8_22. ISBN 978-3-319-23738-1.
  13. ^ a b c Huot P, Fox SH, Brotchie JM (2015). "Monoamine reuptake inhibitors in Parkinson's disease". Parkinsons Dis. 2015: 609428. doi:10.1155/2015/609428. PMC 4355567. PMID 25810948.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.