Dorzolamide

Dorzolamide
Clinical data
Trade namesTrusopt, others
AHFS/Drugs.comMonograph
MedlinePlusa602022
Routes of
administration		eye drops
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding~33%
Elimination half-life4 months
Identifiers
IUPAC name
  • (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.229.271
Chemical and physical data
FormulaC10H16N2O4S3
Molar mass324.43 g·mol−1
3D model (JSmol)
SMILES
  • CCNC1CC(C)S(=O)(=O)c2sc(cc12)S(=O)(=O)N
InChI
  • InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 Y
  • Key:IAVUPMFITXYVAF-XPUUQOCRSA-N Y
 NY (what is this?)  (verify)

Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma.[3] It is used as an eye drop.[3] Effects begin within three hours and last for at least eight hours.[3] It is also available as the combination dorzolamide/timolol.[3][4]

Common side effects include eye discomfort, eye redness, taste changes, and blurry vision.[3] Serious side effects include Steven Johnson syndrome.[3] Those allergic to sulfonamides may be allergic to dorzolamide.[3][5] Use is not recommended in pregnancy or breastfeeding.[5] It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humor.[3]

Dorzolamide was approved for medical use in the United States in 1994.[3] It is available as a generic medication.[5] In 2022, it was the 201st most commonly prescribed medication in the United States, with more than 2 million prescriptions.[6][7]

  1. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
  2. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  3. ^ a b c d e f g h i "Dorzolamide Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 26 March 2019.
  4. ^ "Dorzolamide (Ophthalmic Route) Description and Brand Names". Mayo Clinic. Retrieved 3 November 2023.
  5. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1148. ISBN 9780857113382.
  6. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  7. ^ "Dorzolamide Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
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