Drotaverine

Not to be confused with doravirine.
Drotaverine
Clinical data
Trade namesNo-Spa, Doverin
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, intravenous, intramuscular
ATC code
Legal status
Legal status
  • OTC (tablets), Rx-only (solution for injection) (RU)[1]
Pharmacokinetic data
BioavailabilityHighly variable (~65%), peak at 45–60 min
Protein binding95–98%
MetabolismHepatic
Elimination half-life7–16 hours
Excretion>50% in urine and ~30% in bile[1]
Identifiers
IUPAC name
  • (Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.110.916
Chemical and physical data
FormulaC24H31NO4
Molar mass397.515 g·mol−1
3D model (JSmol)
SMILES
  • O(c1ccc(cc1OCC)\C=C3\c2c(cc(OCC)c(OCC)c2)CCN3)CC
InChI
  • InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13- Y
  • Key:OMFNSKIUKYOYRG-MOSHPQCFSA-N Y
 NY (what is this?)  (verify)

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth and to relieve smooth muscle spasms in the gastrointestinal tract, urinary system, and gall bladder.[2][3][4][5]

It is structurally related to papaverine, and is a selective inhibitor of phosphodiesterase-4, and has no anticholinergic effects.[6]

It is available in Asia, Central and Eastern Europe (Poland,[7] Hungary,[8] Estonia,[9] Latvia,[10] Lithuania[11]) under several brand names.[12] A popular brand is No-Spa, owned by Sanofi). It is distributed by Sanofi as Но-Шпа (No-shpa) in Russia.[13]

  1. ^ a b "Инструкция по применению препарата Но-шпа // No-Spa (tablets) Full Prescribing Information". National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8.
  2. ^ Padubidri V, Anand E (2006). Title Textbook of Obstetrics. BI Publications Pvt Ltd. p. 283. ISBN 9788172252236.
  3. ^ Singh KC, Jain P, Goel N, Saxena A (January 2004). "Drotaverine hydrochloride for augmentation of labor". International Journal of Gynaecology and Obstetrics. 84 (1): 17–22. doi:10.1016/s0020-7292(03)00276-5. PMID 14698825. S2CID 43824027.
  4. ^ "DROTAVERINE: Uses, Side Effects and Medicines | Apollo Pharmacy". www.apollopharmacy.in. Retrieved 2022-05-24.
  5. ^ Cite error: The named reference :0 was invoked but never defined (see the help page).
  6. ^ "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved 9 August 2014.
  7. ^ "No-Spa, 40 mg, tabletki, 20 szt". doz.pl (in Polish). Retrieved 2023-01-09.
  8. ^ "DROTAVERIN-CHINOIN 40 mg tabletta 24 db - PATIKA24 Gyógyszer". www.patika24.hu (in Hungarian). Retrieved 2023-01-09.
  9. ^ "NO-SPA ÕHUKE POLÜMEERKATTEGA TBL 40MG N24 | BENU Veebiap". www.benu.ee (in Ewe). Retrieved 2023-01-09.
  10. ^ "NO-SPA 40 mg tabletes, 24 gab. - Piegāde visā Latvijā | Mēness aptieka". www.e-menessaptieka.lv (in Latvian). Retrieved 2023-01-09.
  11. ^ "Drotaverine - Vaistai.lt". vaistai.lt. Retrieved 2023-01-09.
  12. ^ Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
  13. ^ "Но-шпа — инструкция по применению, дозы, побочные действия, отзывы о препарате: таблетки, покрытые пленочной оболочкой,таблетки,раствор для внутривенного и внутримышечного введения, 20 мг/мл, 40 мг, 40 мг". РЛС® (in Russian). Retrieved 2023-10-26.
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